[摘要]目的 通过对中晚期子宫颈癌病人行低氧放疗加化疗，探讨其对具有造血与免疫功能的骨髓及腹盆部淋巴等正常组织的保护作用及其与病人远期生存的关系。方法 67例子宫颈癌病人均经病理证实。将其按期别不同分层随机分为低氧放疗组(低氧组，34例)和常规放疗组(对照组，33例)。低氧组病人在实施放疗前1～ 2 min内 开始吸入含氧体积分数为0.105的低氧气体，持续至该野照射完毕，每野连续照射不大于5 min，换野时重复上述过程。对照组为常规放疗。两组肿瘤依期别不同给予全盆中平面剂量(DT20～50 Gy)照射，宫旁四分野中平面剂量( DT15～ 34 Gy)照射。两组放疗后给予MOB或FP方案全身化疗。结果 低氧组治疗后外周血白细胞下降平均值为( 1.49± 0.51)×109 /L，对照组为(2.86±0.78)×109 /L，两组比较差异有显著意义( t=2.34，P < 0.05 );低氧组治疗后E花环上升(5.57±1.85)%，LC转化率上升(3.53±1.23)%，而对照组分别下降(3.35± 1.67 )%和( 4.32± 1.52)%，两组比较差异有显著性( t=5.15、2.43，P <0.01);两组5年生存率比较差异有显著性( χ2 =4.65，P <0.05);两组放射性直肠炎和放射性膀胱炎的发生率比较差异也有显著性( χ2 =6.75、3.98，P < 0.01 、0.05)。结论 对中晚期子宫颈癌病人采取低氧放疗加化疗可明显保护其骨髓的造血及细胞免疫功能，改善病人的生存质量，提高病人远期生存率，具有重要临床价值。

    [关键词] 宫颈肿瘤;缺氧;放射疗法;药物疗法;免疫测定;治疗结果

    CLINICAL EFFECT OF HYPOXIA-RADIOTHERAPY PLUS CHEMOTHERAPY ON PATIENTS WITH INTERMEDIATE AND AD-VANCED-STAGE CERVICAL CARCINOMA

    SU YAN， AN YONG-HENG， DING AI-PING， et al

    (Rizhao Women and Children's Health Care Hospital， Rizhao 276800， China)

    [ABSTRACT]ObjectiveTo investigate the relationship between long-term survival and protection of the marrow and lymphoid tissues in pelvis through hypoxic radiotherapy plus chemotherapy for patients with intermediate- and advanced-stage cervi-cal carcinoma. MethodsThis study consisted of 67 patients whose diagnosis was confirmed pathologically. They were divided into two groups at stratified random: hypoxic radiotherapy group (HRG) and conventional radiotherapy group (CRG). The pa-tients in HRG inhaled hypoxic gas (oxygen physical volume: 0.105) for two minutes before radiotherapy till the end of the treat-ment of each field and then repeated. The duration of irradiation to each field was less than five minutes. The patients in the control group (CRG) were only treated with conventional radiotherapy. The irradiation dose in the midpelvic plane was 20-50 Gy depen-ding on the different stages of the cancer. The dose of four-divided-field loaded in lateral cervix was 15-34 Gy. The dose at point A of intracavitary therapy was 15-34 Gy. After the radiation mentioned above ......