[摘要]目的 观察甲地孕酮对晚期胃癌病人化疗所致的厌食、体质量下降、骨髓抑制及胃肠道反应的作用。方法 86例晚期胃癌病人随机分为两组，单用化疗药物组(对照组)41例，应用化疗药物+甲地孕酮组(观察组)45例。结果 观察组食欲增加者50.4%，体质量增加者52.2%，Ⅱ级以上胃肠道反应发生率15.7%，与对照组比较差异有显著性( uc =4.923～7.053，P <0.01)。结论 甲地孕酮配合化疗能明显改善晚期胃癌病人生活质量。

    [关键词] 生活质量;胃肿瘤;抗肿瘤联合化疗方案;甲地孕酮

    COMBINATION OF MEGESTROL WITH CHEMOTHERAPY TO IMPROVE QUALITY OF LIFE IN PATIENTS WITH ADVANCED GASTRIC CANCER

    FU AI-QIN， ZHANG EN-NING

    (Yantai Tumor Hospital， Yantai 264000， China)

    [ABSTRACT]ObjectiveTo investigate the effect of Megestrol on anorexia， nausea， vomiting， weight loss and myelosup-pression caused by chemotherapy. MethodsEighty-six patients with advanced gastric cancer were divided randomly into group Ⅰ ......