[摘要]目的 探讨载脂蛋白H(Apo H)外显子3、8基因多态性与冠心病(CHD)及血脂代谢的关系。方法采用聚合酶链式反应结合限制性片段长度多态分析方法，分析了100例健康人及110例冠心病病人的Apo H外显子3、8基因型，并对血脂进行了测定。结果 冠心病组Apo H 外显子3 GG、GA+AA基因型频率及G、A等位基因频率与对照组比较差异无显著性 ( χ2 =1.56～2.15，P >0.05)。冠心病组Apo H外显子8 GC基因型频率及C等位基因频率显著增高( χ2 =3.91、8.44，P <0.05)。冠心病组Apo H 外显子3 GG、GA+AA基因型病人高密度脂蛋白胆固醇(HDL)显著高于对照组( t′=8.30，t=4.06 ，P <0.05);冠心病组及对照组内基因型间的血脂水平比较无明显差异。冠心病组外显子8 GG、GC基因型病人LDL水平也显著高于对照组( t′=7.97、8.55，P <0.05);冠心病组GC基因型病人的三酰甘油(TG)水平显著高于GG型及对照组的各基因型( t′=4.02 ～4.71，P <0.05)。结论 Apo H外显子3基因多态性与冠心病及血脂代谢无相关性;Apo H外显子8 GC基因型及C等位基因频率与冠心病发病有关，Apo H外显子8基因多态性与TG代谢有关。

    [关键词] 冠状动脉疾病;载脂蛋白类;基因频率;基因型;高脂血症

    RELATIONSHIP BETWEEN APOLIPOPROTEIN H GENE POLYMORPHISM WITH CORONARY HEART DISEASE AND LIPI-DEMIA

    QU CHUN-YAN， CUI GUO-FANG， TANG AI-PING

    (Department of Internal Medicine， Maternal and Child Health Hospital of Laoshan， Qingdao 266101， China)

    [ABSTRACT]ObjectiveTo study the relationship between the polymorphism of apolipoprotein H (Apo H) exon 3 and exon 8 with coronary heart disease (CHD) and lipidemia. MethodsPolymerase chain reaction and technique of restriction frag-ment length polymorphism were used to detect the genotypes of Apo H exon 3 and exon 8 in 110 patients with CHD and 100 healthy subjects. Lipidemia was also detected. ResultsThere was no difference between CHD group and control group in terms of the frequency of Apo H exon 3 GG ......