[摘要]目的 通过对病理性瘢痕组织中c-fos和5-HT表达变化的研究，探讨其与病理性瘢痕痛痒和增生的关系。方法 利用免疫组化方法检测病理性瘢痕和正常皮肤中c-fos和5-HT的表达情况。结果 痛痒的病理性瘢痕组织中c-fos、5-HT的表达显著高于正常皮肤组织和非痛痒的瘢痕组织( F=19.86、17.61，q=5.43～8.84， P < 0.01);非痛痒的瘢痕组织中c-fos的表达显著高于正常皮肤( q=3.41，P <0.01)，而5-HT表达无明显差异( P > 0.05 )。结论 c-fos、5-HT表达增高可能导致病理性瘢痕临床痛痒症状的发生，c-fos表达增高可能与病理性瘢痕的形成、发展有关。

    [关键词] 瘢痕;原癌基因蛋白质c-fos;血清素;疼痛;瘙痒症;增生

    EXPRESSIONS OF c-fos AND 5-HT IN ABNORMAL SCARS AND THEIR RELATIONSHIP WITH HYPERPLASIA ， ITCH AND PAIN

    CHEN ZHEN-YU， ZHANG WEI-NA， MIAO YUAN-XIN， et al

    (Department of Plastic and Cosmetic Surgery， The Affiliate Hospital of Qingdao University Medical College， Qingdao 266003， China)

    [ABSTRACT]ObjectiveTo study the expression of two mediums， i.e. c-fos and 5-HT， in abnormal scars and their rela-tionship with hyperplasia， itch and pain. MethodsThe immunohistochemistry method was applied to study expressions of c-fos and 5- hydroxytryptamine (5-HT) in pathologic scars and normal skin. ResultsIn the itching or painful scars， c-fos and 5-HT expressions were all significantly higher than those in non-itching or painful scars and normal skin ( F=19.86 ......