溃疡性结肠炎;姜黄素;(期刊论文)

姜黄素对大鼠溃疡性结肠炎的影响

http://www.100md.com 《咸宁学院学报(医学版)》 2006年第4期

溃疡性结肠炎;姜黄素;,白细胞介素1β；白细胞介素6；白细胞介素4,,溃疡性结肠炎;姜黄素;,白细胞介素1β；白细胞介素6；白细胞介素4,1材料和方法

     摘要: 目的探讨姜黄素(Cur)对大鼠溃疡性结肠炎(UC)的保护作用及其机制。方法采用三硝基苯磺酸(TNBS)灌肠制备大鼠UC模型,将动物随机分为正常对照组、TNBS模型组、5氨基水杨酸组、Cur组4组。观察各组大鼠肠组织大体形态和组织学改变,分别测定血清和肠组织中IL1β、IL6和IL4浓度。结果 UC大鼠血清和肠组织中 IL1β、IL6浓度显著高于正常对照组，IL4浓度显著低于正常对照组( P < 0. 01)。Gur组UC大鼠IL1β、IL6浓度明显减少，IL4浓度明显升高( P < 0. 01),结肠组织大体形态和组织学评分明显好转。结论 Cur可能通过抗炎作用使促炎性细胞因子IL1β和IL6浓度减少，抗炎性细胞因子IL4浓度增加，对溃疡性结肠炎起保护作用。

    关键词:溃疡性结肠炎;姜黄素; 白细胞介素1β；白细胞介素6；白细胞介素4

    The Protective Effect of Curcum in TNBSinduced Ulcerative Colitis in Rats

    CHEN Guizhi，LUO Lidan，QIN Lingzhi,et al

    (Xianning College, Xianning Hubei 437100, China)

    ABSTRACT:Objective To observe the effects of Curcumin (Cur) in TNBSinduced ulcerative colitis in rats and its mechanisms. Methods Rat ulcerative colitis model was induced by trinitrobenzene-sulfacid (TNBS). The rats randomly divided into 4 groups: normal group, model group, 5ASA group and Cur group. The levels of IL1β、LI6 and IL4 in the serum and colon tissue were determined. The macroscopical and hisological changes of the colon were also evaluated. Results It showed that the levels of IL1βand IL6 in the serum and colon tissue in the model group were significant increased while the levels of IL4 were significant decreased than the normal group. Treatment with Cur evidently reduced the levels of IL1βand IL6 and significantly increased IL4 level(P<0. 01).The macroscopic and histological damages were significantly decreased. Conclusion Curcumin could protect ulcerative colitis in rats by suppression of increased IL1β,LI6 and increasing the IL4 contents.KEY WORDS:Ulcerative Colitis; Curcumin; Interleukin1β；Interleukin6；Interleukin4 ......

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