血小板活化因子;_狼疮性肾炎;_病理_

血小板活化因子与狼疮性肾炎不同病理类型的关系研究

http://www.100md.com 《河北北方学院学报》 2006年第4期

血小板活化因子;,狼疮性肾炎;,病理,,血小板活化因子;,狼疮性肾炎;,病理,1资料与方法,2结果,3讨论,参考文献

     【摘要】目的: 进一步了解血小板活化因子(PAF)与狼疮性肾炎(LN)病理类型的关系。方法: 对35例不同病理类型的LN患者与31例正常对照患者的血浆和尿液PAF水平进行比较。结果: LN患者血浆及尿液PAF水平均比对照组显著增高(P<005)，且随病理损伤程度的加重其水平亦增高；血浆和尿液PAF水平与病变程度之间均存在密切相关(P<001)；血浆PAF水平与尿液PAF水平之间亦存在密切相关(P<001)。结论: PAF水平可作为判断LN免疫病理损伤程度的重要指标。

    【关键词】血小板活化因子; 狼疮性肾炎; 病理

    Study on the Relationship between Levels of Platelet Activating

    Factor and Pathological Classification in Lupus Nephritis

    LIU Hua, LIU Shengjun, LI Yue

    The First Affiliated Hospital, Hebei North University, Zhangjiakou, 075000, Hebei，China

    【ABSTRACT】 Objective:To investigate the relation between platelet activating factor(PAF) and lupus nephritis(LN). Methods: Plasma and urinary PAF level of 35 LN patients with different pathologic changes were compared with those of normal controls. Results: Plasma and urinary PAF levels in LN were significantly higher than that in normal controls(P<005),and they increased as kidney injury aggravated.There was significant difference among patients with different pathological classification(P<001). Conclusion: PAF can serve as an important index for the severity of kidney immune pathological injury. ......

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