组织芯片；免疫组化；乳腺癌_

组织芯片技术在乳腺癌相关指标检测中的应用

http://www.100md.com 《河北北方学院学报》 2006年第4期

组织芯片；免疫组化；乳腺癌,,组织芯片；免疫组化；乳腺癌,1材料与方法,2结果,3讨论,参考文献

     【摘要】目的:探讨组织芯片免疫组化方法在乳腺癌相关指标检测中的应用。方法：采用组织芯片免疫组化和传统免疫组化的方法分别检测了183例和30例乳腺癌组织中MMP2，MMP9， MMP13的表达水平。结果：组织芯片免疫组化染色与传统免疫组化染色不存在统计学差异(P>005)。结论：高通量组织芯片免疫组化的方法在乳腺癌相关指标检测中可一次对多个样本进行多指标检测，大大节省了人力、物力和财力，值得进一步推广使用。

    【关键词】组织芯片；免疫组化；乳腺癌

    The Application of Microarray Immunohistochemical Technique in

    the Detection of the Index Correlated with Breast Cancer

    LI Hongtao1, NING Liansheng2, ZHANG Bin2

    1. Department of Oncology, The First Affiliated Hospital， Heibei North University,

    Zhangjiakou, 075000, Hebei， China; 2. Department of Breast, The Affiliated Cancer

    Treatment Hospital， Tianjin Medical University, Tianjin, 300070, China

    【ABSTRACT】 Objective: To investigate the application of Microarray immunohistochemical technique in the detection of the index correlated with breast cancer. Methods: MMP2, MMP9 and MMP13 were detected by Microarray immunohistochemical technique and traditional immunohistochemical technique in 183 patients and 30 patients with breast cancer respectively. Results: Microarray immunohistochemical technique has no significant difference compared with traditional immunohistochemical technique. (P>005). Conclusion: Highflux Microarray immunohistochemical technique can detect several indexes for many samples one time in the detection of the index correlated with breast cancer. It could save manpower, materials and financial resources. It is worth to be spread and applicated. ......

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