乳腺癌；基质金属蛋白酶；组织芯片；诊断；预后_

乳腺癌组织中MMP2、MMP9表达及预后意义

http://www.100md.com 《河北北方学院学报》 2006年第5期

乳腺癌；基质金属蛋白酶；组织芯片；诊断；预后,,乳腺癌；基质金属蛋白酶；组织芯片；诊断；预后,1材料与方法,2结果,3讨论,参考文献

     【摘要】目的：探讨基质金属蛋白酶MMP2、MMP9在乳腺癌中的表达情况及与临床预后的关系。方法：采用组织芯片及免疫组化SP法检测了183例乳腺癌组织中MMP2、MMP9的表达水平。结果：①乳腺癌组织中MMP2和MMP9的阳性表达率分别为770%(141/183)和656%(120/183)。乳腺癌组与良性对照组MMP2、MMP9的表达具有显著性差异( P<001)。 ②MMP2的表达与肿瘤大小有关(P=0010)，与临床TNM分期、淋巴结转移状态、组织学分级密切相关(P均<001)；MMP9的表达与组织学分级有关(P=0012)，与肿瘤大小、临床TNM分期、淋巴结转移状态密切相关(P均<001)； MMP2和MMP9的表达与年龄、月经状态、病理类型以及雌孕激素受体状态无关。③MMP2、MMP9高表达组10年生存率均低于低表达组。结论：MMP2、MMP9均可作为乳腺癌患者预后判断的指标。

    【关键词】乳腺癌；基质金属蛋白酶；组织芯片；诊断；预后

    Expressions and Prognosis Importance of MMP2 and MMP9 in Breast Cancer

    LI Hongtao, NING Liansheng, ZHANG Bin

    Department of Oncology,The First Affiliated Hospital，Heibei North University,Zhangjiakou,075000,Hebei,China;Department of Breast, The Cancertreating Hospital，Tianjin Medical University, Tianjin, 300070,China

    【ABSTRACT】 Objective: To observe the expressions of MMP2 and MMP9 in breast cancer, and investigate their correlation with the clinical prognosis for breast cancer Methods: MMP2 and MMP9 were detected by Microarray and SP immunohistochemical technique in 183 patients with breast cancerResults: ①The expression levels of MMP2 (770%) and MMP9 (656%) in the breast cancer tissues were significantly higher than those of benign breast diseases (P <001)②MMP2 was correlated with the tumor size (P =0010), and significantly correlated with clinical TNM stage, histological grade, and lymph node status MMP9 was correlated with the histological grade (P =0012), and significantly correlated with tumor size, clinical TNM stage, and lymph node status (P <001) MMP2 and MMP9 had no correlation with age, pathological type, the status of ER and PR③The survival rate of 10 years in the group of MMP2 and MMP9 overexpression was lower than that of lowexpression the group.Conclusion: MMP2 and MMP9 all could serve as markers for prognosis judgment of breast cancer patients. ......

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