干、鲜壁虎冻干粉对小鼠H22肝癌体内外抑制作用
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杨金霞, 王学美, 朱 伟, 富 宏, 刘庚信
壁虎;抗肿瘤作用;H22肝癌;小鼠杨金霞,王学美,朱伟,富宏,刘庚信.干、鲜壁虎冻干粉对小鼠H22肝癌体内外抑制作用. 世界华人消化杂志2007;15(2)157-160,杨金霞,王学美,朱伟,富宏,刘庚信,通讯作者:,电话:,&#
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杨金霞, 王学美, 朱伟, 富宏, 刘庚信, 北京大学第一医院中西医结合研究室 北京市 100034国家自然科学基金资助项目, No. 30472137
国家中医药管理局资助项目, No. 04-05ZP04
通讯作者: 王学美, 100034, 北京市西城区西什库大街8号, 北京大学第一医院中西医结合研究室. wangxuemei64@sohu.com
电话: 010-66551122-3053 传真: 010-66551328
收稿日期: 2006-08-21 接受日期: 2006-10-25
Anti-tumor effects of dry and fresh Gekko Swinhonis Gunther freeze-dried powders on mouse H22 hepatocellular carcinoma in vivo and in vitro
Jin-Xia Yang, Xue-Mei Wang, Wei Zhu, Hong Fu, Geng-Xin Liu
Jin-xia Yang, Xue-Mei Wang, Wei Zhu, Hong Fu, Geng-Xin Liu, Department of Integrated Chinese Medicine and Western Medicine, the First Hospital of Peking University, Beijing 100034, China
Supported by National Natural Science Foundation of China, No. 30472137, and the Fund from State Administration of Traditional Chinese Medicine, No. 04-05ZP04
Correspondence to: Xue-Mei Wang, Department of Integrated Chinese Medicine and Western Medicine, the First Hospital of Peking University, 8 Xishiku Street, Beijing 100034, China. wangxuemei64@sohu.com
Received: 2006-08-21 Accepted: 2006-10-25
AbstractAIM: To investigate the anti-tumor activity of dry and fresh Gekko Swinhonis Gunther freeze-dried powder (DGFP and FGFP) on mouse H22 hepatocellular carcinoma in vivo and in vitro.
METHODS: The mice bearing H22 tumor cells were used in this study. After treatment with DGFP and FGFP in vivo and in vitro, the anti-tumor effects as well as the weights of thymus and spleen were measured, and the proliferation of H22 cells was detected by MTT assay.
RESULTS: The tumor inhibition rates of low-, moderate- and high-dose DGFP were 25.6%, 40.0%, 48.5%, while those of FGFP were 20.7%, 27.4%, and respectively, in vivo. As compared with those in 5-FU group, the weights together with the indexes of thymus and spleen were markedly increased (P < 0 ......
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