整合素与胰腺癌
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何 度, 张秀辉
整合素;胰腺癌;浸润;转移,何度,张秀辉,通讯作者:,收稿日期:,接受日期:,Rolesofintegrinsinpancreaticadenocarcinoma,DuHe,Xiu-HuiZhang,Correspondenceto:,Received:,Accepte
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何度, 张秀辉, 四川大学华西医院病理科 四川省成都市 610041
通讯作者: 张秀辉, 610041, 四川省成都市国学巷37号, 四川大学华西医院病理科. zhangxiuhui1955@126.com
收稿日期: 2006-08-07 接受日期: 2006-11-02
Roles of integrins in pancreatic adenocarcinoma
Du He, Xiu-Hui Zhang
Du He, Xiu-Hui Zhang, Department of Pathology, West China Hospital, Chengdu 610041, Sichuan Province, China
Correspondence to: Xiu-Hui Zhang, Department of Pathology, West China Hospital, 37 Guoxue Xiang, Chengdu 610041, Sichuan Province,China. zhangxiuhui1955@126.com
Received: 2006-08-07 Accepted: 2006-11-02
AbstractIntegrins, serving as transmembrane proteins, play major roles in cell-extracellular matrix adhesions, and they can introduce extracellular signals into the cells, alter cellular morphology and influence cell motility as well as contribute to tumor invasion and metastasis. One of the major causes of low resection rates and extremely poor survival rates is its extraordinary local tumor progression and early systemic dissemination. Being a kind of adhesion molecules associating cells with extracellular matrix, integrins play a variety of roles in the process of invasion and metastasis in pancreatic adenocarcinoma.
Key Words:Integrin; Pancreatic adenocarcinoma; Invasion; Metastasis
He D, Zhang XH. Roles of integrins in pancreatic adenocarcinoma. Shijie Huaren Xiaohua Zazhi 2007;15(2):151-156
摘要整合素为一类跨膜蛋白, 是介导细胞与细胞外基质黏附的主要黏附分子. 他将细胞外的信号传入细胞内调节细胞生长、改变细胞形态、影响细胞运动, 并在肿瘤侵袭和转移的过程中起重要作用. 胰腺癌手术切除率低死亡率高的重要原因之一是肿瘤早期即能发生局部浸润和远处器官转移, 整合素作为细胞与细胞外基质的黏附分子, 在胰腺癌侵袭及转移过程中发挥多重作用.
关键词: 整合素; 胰腺癌; 浸润; 转移
何度, 张秀辉. 整合素与胰腺癌. 世界华人消化杂志 2007;15(2):151-156
0 引言
细胞外基质(extracellular matrix, ECM)是细胞生长的土壤, 在细胞的基本生命活动中起重要作用: 调控细胞存活或凋亡[1-4]、影响细胞形态[5]、调节细胞增殖[6]、控制细胞分化[7]、影响细胞迁移[8-10]等. 细胞通过自身整合素受体将细胞外的信号传导入细胞内, 参与白细胞黏附[11]、游出、趋化[12], 血液凝固[13], 受精卵植入[14-15], 创伤愈合[16], 细胞恶性转化[17-18], 肿瘤侵袭[19-23]等过程 ......
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