烧伤应激对胃动力的影响
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刘 婧, 李兆申
Toll样受体;肝硬化;抗生素;流式细胞术;单克隆抗体刘婧，李兆申.烧伤应激对胃动力的影响. 世界华人消化杂志2007;15(2)134-139,刘婧,李兆申,通讯作者:,电话:, 传真:,收稿日期:,接受日期:,Effectofburn
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刘婧, 中国人民解放军总医院南楼消化内镜中心 北京市 100853
李兆申, 第二军医大学附属长海医院消化科 上海市 200433
通讯作者: 刘婧, 100853, 北京复兴路28号, 中国人民解放军总医院南楼消化内镜中心. liujing7376@sohu.com
电话: 010-66937622 传真: 010-66935470
收稿日期: 2006-10-29 接受日期: 2006-11-10
Effect of burn stress on gastric motility
Jing Liu, Zhao-Shen Li
Jing Liu, Endoscopic Centre of South Building, General Hospital of Chinese PLA, Beijing 100853, China
Zhao-Shen Li, Department of Gastroenterology, Changhai Hospital, the Second Military Medical University, Shanghai 200433, China
Correspondence to: Jing Liu, Endoscopic Centre of South Building, General Hospital of Chinese PLA, Beijing 100853, China. liujing7376@sohu.com
Received: 2006-10-29 Accepted: 2006-11-10
AbstractAIM: To investigate the effect of burn stress on gastric motility as well as the changes of related neuropeptides.
METHODS: Radioimmunological assay was performed to detect the dynamic changes of related neuropeptides, including CCK-8, vasoactive intestinal peptide (VIP), somatostatin (SS), and gastrin (GAS) in patients with burn injury and healthy volunteers using ambulatory manometry. Strain-gauge transducers were pre-equipped at the antrum of rats to establish the models of burn injury (30% full skin scalding), and gastric motility and the changes of plasma VIP and CCK-8 contents were recorded before and after modeling. Exogenous peptides (VIP, CCK-8) were intravenously administrated to determine the gastric motor responses.
RESULTS: There were no complete migrating motor complex (MMC) cycles in burn patients. Interdigestive and postprandial gastric motility patterns were mainly resting state without constant phase or with low ampulitude contraction, persistent and irregularly high-frequency contraction and propagated burst activity. In patients with burn injury, the plasma levels of CCK-8, SS, and GAS were significantly higher than those in the controls (5 ......
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