胃癌组织中EGFR和COX-2表达的意义及其相关性
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肖炜明, 施瑞华, 丁岩冰, 龚卫娟, 丁永玲, 薛 艳
胃癌;表皮生长因子受体;环氧合酶-2;相关性;侵袭;转移肖炜明,施瑞华,丁岩冰,龚卫娟,丁永玲,薛艳.胃癌组织中EGFR和COX-2表达的意义及其相关性. 世界华人消化杂志2007;15(2)123-128 胃癌COX-2和EGFR蛋白表达(EnVision×200).A中分
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肖炜明, 丁岩冰, 丁永玲, 薛艳, 扬州大学第二临床医学院消化科 江苏省扬州市 225001
施瑞华, 南京医科大学附属第一医院消化科 江苏省南京市 210029
龚卫娟, 扬州大学医学院免疫学教研室 江苏省扬州市 225001
肖炜明, 硕士, 副主任医师, 主要从事消化道肿瘤方面的研究.江苏省卫生厅135工程重点人才基金, No. RC2002053
通讯作者: 施瑞华, 210029, 江苏省南京市, 南京医科大学第一附属医院消化科. ruihuashi@126.com
电话: 025-83674636
收稿日期: 2006-10-20 接受日期: 2006-11-10
Expression of epidermal growth factor receptor and cyclooxygenase-2 and their correlations in gastric carcinoma
Wei-Ming Xiao, Rui-Hua Shi, Yan-Bing Ding, Wei-Juan Gong, Yong-Ling Ding, Yan Xue
Wei-Ming Xiao, Yan-Bing Ding, Yong-Ling Ding, Yan Xue, Department of Gastroenterology, the Second Clinical Medical College of Yangzhou University, Yangzhou 225001, Jiangsu Province, China
Rui-Hua Shi, Department of Gastroenterology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Wei-Juan Gong, Department of Immunology, Medical Collage of Yangzhou University, Yangzhou 225001, Jiangsu Province, China
Supported by the Key Talent Foundation from the ‘135’ Project of Health Department, Jiangsu Province, No. RC2002053
Correspondence to: Rui-Hua Shi, Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province,China. ruihuashi@126.com
Received: 2006-10-20 Accepted: 2006-11-10
AbstractAIM: To investigate the expression of epidermal growth factor receptor (EGFR) and cyclooxygenase-2 (COX-2) as well as their correlations in gastric carcinoma.
METHODS: Immunohistochemistry was performed to detect the expression of EGFR and COX-2 in 61 cases of gastric cancer and 20 cases of cancer-adjacent tissues, while Western blot was used to examine the protein expression of EGFR and COX-2 in 10 cases of gastric cancer and their corresponding cancer-adjacent tissues ......
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