Survivin在大肠癌组织中表达的意义及其与Bcl-2的关系
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耿婉如, 李 宁, 余 琦, 周会芹, 许红民
大肠癌;免疫组化;Survivin;Bcl-2;预后,耿婉如,李宁,余琦,周会芹,许红民,通讯作者:,SignificanceofSurvivinexpressionanditscorrelationwithBcl-2prote
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耿婉如, 军医进修学院学员队 北京市 100082
李宁, 余琦, 周会芹, 许红民, 中国人民解放军总医院第二附属医院病理科 北京市 100091
通讯作者: 许红民, 100091, 北京市, 中国人民解放军总医院第二附属医院病理科. xuhongmin@yahoo.com.cn
电话: 010-66775260
收稿日期: 2006-08-09 接受日期: 2006-11-03
Significance of Survivin expression and its correlation with Bcl-2 protein expression in colorectal carcinoma
Wan-Ru Geng, Ning Li, Qi Yu, Hui-Qin Zhou, Hong-Min Xu
Wan-Ru Geng,Postgraduate Team, Postgraduate Medical School of Chinese PLA, Beijing 100082, China
Ning Li, Qi Yu, Hui-Qin Zhou, Hong-Min Xu,Department of Pathology, the Second Affiliated Hospital of General Hospital of Chinese PLA, Beijing 100091, China
Correspondence to:Hong-Min Xu, Department of Pathology, the Second Affiliated Hospital of General Hospital of PLA, Beijing 100091, China. xuhongmin@yahoo.com.cn
Received:2006-08-09 Accepted: 2006-11-03
Abstract
AIM: To study the expression of Survivin and its correlation with expression of Bcl-2 protein in colorectal carcinoma.
METHODS: The expression of Survivin and Bcl-2 protein was evaluated by immunnohistochemistry in 52 case of colorectal carcinoma. The relationship between Survivin expression and clinical indexes as well as Bcl-2 expression was analyzed.
RESULTS: Survivin was expressed in 27 of 52 (51.9%) colorectal carcinoma cases. The expression of Survivin showed no correlation with the age, sex, tumor location, size, differentiation degree, pathologic types and lymph node metastasis (P > 0.05). The 5-year survival rate was lower in patients with high Survivin expression than that in those with low Survivin expression (52.94% vs 83.33%, P = 0.0304). There was no significant relationship between Survivin and Bcl-2 expression (P > 0.05).
CONCLUSION: Survivin expression may play a strong inhibitory role in the apoptosis of colorectal cancer cells, and the patients with high Survivin expression have an unfavorable prognosis ......
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