糖尿病胃轻瘫的诊断及发病机制
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刘 云, 孙 岩, 薛绮萍, 李建民
症状评分;胃肠道激素;小钡条排空试验;糖尿病胃轻瘫,刘云,孙岩,薛绮萍,李建民,通讯作者:,Diagnosisandpathogenicmechanismofdiabeticgastroparesis,YunLiu,YanSun,Qi-PingXue,J
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刘云, 孙岩, 薛绮萍, 南京医科大学第一临床医学院老年医学科 江苏省南京市 210008
李建民, 南京医科大学细胞生物学系 江苏省南京市 210029
江苏省教委自然科学基金资助项目, No. 01KJB320009
通讯作者: 李建民, 210029, 江苏省南京市鼓楼区汉中路140号, 南京医科大学细胞生物学系. jianminli@njmu.edu.cn
电话: 025-86863153 传真: 025-86204389
收稿日期: 2006-10-26 接受日期: 2006-11-16
Diagnosis and pathogenic mechanism of diabetic gastroparesis
Yun Liu, Yan Sun, Qi-Ping Xue, Jian-Min Li
Yun Liu, Yan Sun, Qi-Ping Xue, Department of Geratology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210008, Jiangsu Province, China
Jian-Min Li,Department of Cell Biology, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Supported bythe Natural Science Foundation of Education Committee of Jiangsu Province, No. 01KJB320009
Correspondence to:Jian-Min Li, Department of Cell Biology, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China. jianminli@njmu.edu.cn
Received:2006-10-26 Accepted:2006-11-16
Abstract
AIM: To evaluate the clinical diagnosis and explore the pathogenic mechanisms of diabetic gastroparesis.
METHODS: A total of 38 in-hospital patients with diabetes were included in this study. Biochemical method and radioimmunoassay (RIA) were used to detect the levels of plasma glucoses, glycosylated hemoglobin (GHG), gastrin, motilin and glucagons. The autonomic nerve function and barium strip emptying time were used to make diagnosis of diabetic gastroparesis.
RESULTS: The levels of fast blood glucose (FBG), postprandial blood glucose (PBG) and GHG were significantly higher in diabetic patients with abnormal gastric emptying than those with normal gastric emptying (FBG: 12.53 ± 4.13 mmol/L vs 7.12 ± 1.37 mmol/L, P < 0.01; PBG: 19.79 ± 5.69 mmol/L vs 14.11 ± 4.21 mmol/L, P < 0.05; GHG: 9.73% ± 2.39% vs 7.26% ± 1.96%, P < 0.05). Meanwhile, high levels of serum motilin, gastrin, and glucagons were detected in diabetic patients with abnormal gastric emptying ......
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