高胆固醇血症兔Oddi括约肌细胞钾离子通道活性的改变
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张孝勇, 马 进, 杜 滂, 马克军, 王亚蓉, 魏经国
高胆固醇血症;Oddi括约肌;收缩反应;钾离子通道,张孝勇,杜滂,马克军,王亚蓉,魏经国,马进,张孝勇,通讯作者:,ChangesinpotassiumionchannelactivityoftheOddi’ssphinctersmo
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张孝勇, 杜滂, 马克军, 王亚蓉, 魏经国, 中国人民解放军第四军医大学唐都医院放射科 陕西省西安市 710038
马进, 中国人民解放军第四军医大学航空航天生理学教研室 陕西省西安市 710032
张孝勇, 2004年获医学硕士学位, 现为第四军医大学博士研究生, 主要从事胆系疾病的分子病理学研究.
国家自然科学基金资助项目, No. 30470787
通讯作者: 魏经国, 710038, 陕西省西安市灞桥区新寺路1号, 第四军医大学唐都医院放射科. zhang-xy@fmmu.edu.cn
电话: 029-84773135 传真: 029-84777163
收稿日期: 2006-11-01 接受日期: 2006-11-28
Changes in potassium ion channel activity of the Oddi’s sphincter smooth muscle cells from hypercholesterolemic rabbits
Xiao-Yong Zhang, Jin Ma, Pang Du, Ke-Jun Ma, Ya-Rong Wang, Jing-Guo Wei
Xiao-Yong Zhang, Pang Du, Ke-Jun Ma, Ya-Rong Wang, Jing-Guo Wei,Department of Radiology, Tangdu Hospital of the Fourth Military Medical University, Xi'an 710038, Shaanxi Province, China
Jin Ma,Department of Aerospace Physiology, the Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China
Supported byNational Natural Science Foundation of China, No. 30470787
Correspondence to:Jing-Guo Wei, Department of Radiology, Tangdu Hospital of Fourth Military Medical University, Xi'an 710038, Shaanxi Province, China. tdradio1@fmmu.edu.cn
Received:2006-11-01 Accepted:2006-11-28
Abstract
AIM: To study the changes of the contractile responses and potassium ion channel activity in sphincter of Oddi (SO) from rabbits with hypercholesterolemia (HC), and elucidate the underlying mechanisms responsible for these changes.
METHODS: A total of 24 New Zealand female rabbits were divided randomly into control group (n = 12) and HC group (n = 12). SO muscle rings were dissociated from the rabbits in both groups in vitro. The contractile responses of SO to potassium chloride (KCl) was observed firstly. Then the contractile responses evoked by tetraethylammonium (TEA) and 4-aminopyridine (4-AP) were measured. Western blot was employed to examine the expression of potassium ion channels in tissues of HC and control group ......
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