免疫因素在肝纤维化过程中的作用的研究进展
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宗 蕾, 陆伦根
肝纤维化;免疫因素;免疫细胞;细胞因子;生长因子,宗蕾,陆伦根,陆伦根,通讯作者:,Researchprogressonrolesofimmunefactorsindevelopmentofhepaticfibrosis,LeiZong,Lun-
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宗蕾, 陆伦根, 上海交通大学医学院附属仁济医院消化内科, 上海市消化疾病研究所 上海市 200001
陆伦根, 教授, 主任医师, 博士生导师, 主要从事消化疾病的基础和临床研究工作.
上海市重点学科建设项目, No. Y0205
上海市科学技术委员会基金资助项目, No. 054009618
通讯作者: 陆伦根, 上海市, 上海交通大学医学院附属仁济医院消化内科. lungenlu1965@yahoo.com
电话: 021-63364118 传真: 021-63112874
收稿日期: 2006-11-16 接受日期: 2006-12-04
Research progress on roles of immune factors in development of hepatic fibrosis
Lei Zong, Lun-Gen Lu
Lei Zong, Lun-Gen Lu,Department of Gastroenterology, Renji Hospital, Shanghai Jiao Tong University School of Medicine; Shanghai Institute of Digestive Disease, Shanghai 200001, China
Supported bythe Fund for the Key Subject Construction Program of Shanghai Municipality, No. Y0205 and the Science and Technology Committee Foundation of Shanghai Municipality, No. 054009618
Correspondence to:Lun-Gen Lu, Department of Gastroenterology, Renji Hospital, Shanghai Jiao Tong University School of Medicine; Shanghai Institute of Digestive Disease, Shanghai 200001, China. lungenlu1965@yahoo.com
Received:2006-11-16 Accepted:2006-12-04
Abstract
Hepatic fibrosis is a wound-healing process responsive to a variety of factors, and it is also a pathological change caused by the imbalance of synthesis, degradation and deposition of extracellular matrix (ECM) during tissue repair. The changes of many cells, cytokines and ECM are involved in the formation of liver fibrosis, during which the activation of hepatic stellate cells (HSCs) as well as their transforming into myofibroblasts is the central step. Various agents take HSCs as the final target cells and stimulate them to transform into myofibroblasts. Many factors affect the formation of hepatic cirrhosis, but not every one is illuminated completely. Immune suppression accelerates the process according to clinical data. The process speeds up in patients with co-infection of hepatitis C virus (HCV) and human immunodeficiency virus (HIV) and liver transplantation that needs long-term treatment of immunosuppressive drugs ......
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