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灵芝孢子油对化学性肝损伤的保护作用
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     【摘要】 目的 探讨灵芝孢子油对化学性肝损伤的保护作用。方法 对昆明种小鼠每日经口分别灌胃给予0.33g/kg、0.67g/kg和2.00g/kg的灵芝孢子油。30天后,以0.1ml/10g BW的剂量一次性经腹腔注射给予0.125%CCl4(四氯化碳)。结果 0.67g/kg和2.00g/kg剂量组的血清谷丙转氨酶(ALT)、谷草转氨酶(AST)水平降低,与CCl4对照组比较(P<0.05);2.00g/kg剂量组发生肝细胞坏死的动物例数明显减少,病变程度减轻,坏死评分低于CCl4对照组(P<0.01)。结论 灵芝孢子油对CCl4化学性肝损伤具有保护作用。

    【关键词】 灵芝孢子油 四氯化碳 肝损伤

    【Abstract】 Objective To explore the protective effects of ganderoma lucium oil on chemical liver injury.Methods KM mice were given ganderoma lucium oil orally at the dose of 0.33g/kg,0.67g/kg and 2.00g/kg daily.30 days later,0.10ml/kg (0.125%)CCl4 were intraperitoneally injected.Results (1)The serum ALT and AST levels of 0.67g/kg and 2.00g/kg group were significantly decreased compared with the CCl4 control group.(2)The animal amount of happening hepatic cell necrosis changes in 2.00g/kg group was lowered ......

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