大肠癌E-cadherin, β-catenin, MMP-7表达及其临床意义
http://www.100md.com
顾国利, 魏学明, 王石林, 任 力, 郑爱民, 黄蓉蓉, 胡益云
大肠癌;基质金属蛋白酶-7;上皮钙黏附蛋白;b-连接素;组织病理;免疫组化顾国利,魏学明,王石林,任力,郑爱民,黄蓉蓉,胡益云.大肠癌E-cadherin,b-catenin,MMP-7表达及其临床意义. 世界华人消化杂志2007;15(4)375-380 E-cad,β-c
 |
| 第3页 |
 |
| 第1页 |
参见附件。
顾国利, 魏学明, 王石林, 郑爱民, 黄蓉蓉, 中国人民解放军空军总医院普通外科 北京市 100036
任力, 胡益云, 中国人民解放军空军总医院病理科 北京市 100036
顾国利, 硕士, 主治医师, 讲师, 主要从事普外科临床肿瘤学的研究.
通讯作者: 魏学明, 100036, 北京市中国人民解放军空军总医院普通外科. kzwxm@163.com
电话: 010-68410099-6302
收稿日期: 2006-11-03 接受日期: 2006-11-28
Expression of E-cadherin, β-catenin, matrix metalloproteinase-7 and their significances in colorectal carcinoma
Guo-Li Gu, Xue-Ming Wei, Shi-Lin Wang, Li Ren, Ai-Min Zheng, Rong-Rong Huang, Yi-Yun Hu
Guo-Li Gu, Xue-Ming Wei, Shi-Lin Wang, Ai-Min Zheng, Rong-Rong Huang, Department of General Surgery, General Hospital of Chinese PLA Air force, 100036 Beijing, China
Li Ren, Yi-Yun Hu, Department of Pathology, General Hospital of Chinese PLA Air force, 100036 Beijing, China
Correspondence to: Xue-Ming Wei, Department of General Surgery, General Hospital of Chinese PLA Air force, 100036 Beijing, China. kzwxm@163.com
Received: 2006-11-03 Accepted: 2006-11-28
AbstractAIM: To detect expression of E-cadherin, b-catenin and matrix metalloproteinase-7 (MMP-7) as well as their correlations in colorectal carcinoma (CRC).
METHODS: Immunohistochemistry was used to detect the expression of E-cadherin, b-catenin and MMP-7 protein in 60 specimens of CRC and 8 specimens of normal colorectal tissues. The corresponding clinical data were analyzed retrospectively.
RESULTS: The positive rates of E-cadherin, normal b-catenin, abnormal b-catenin and MMP-7 expression in CRC were 73.3%, 66.7%, 63.3% and 73.3%, respectively, which were significantly correlated with the depth of invasion and lymph node metastasis, but not with the age, sex and tumor size or position and differentiation of the patients’. The normal expression of b-catenin was positively correlated with E-cadherin expression (r = 0.359,P = 0.005) in CRC, but negatively correlated with the abnormal expression of b-catenin (r = -0 ......
您现在查看是摘要介绍页，详见PDF附件。