H2受体阻滞剂联合多潘立酮对肝硬化患者门脉血流的影响
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达 炜, 陈金联, 朱金水, 陈尼维, 孙 群, 陈维雄
肝硬化;门脉系统;H2受体阻滞剂;多潘立酮;多普勒超声达炜,陈金联,朱金水,陈尼维,孙群,陈维雄.H2受体阻滞剂联合多潘立酮对肝硬化患者门脉血流的影响. 世界华人消化杂志2007;15(4)408-411,达炜,陈金联,朱金水,陈尼维
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达炜, 陈金联, 朱金水, 陈尼维, 孙群, 陈维雄, 上海交通大学附属第六人民医院消化内科 上海市 200233
通讯作者: 达炜, 200233, 上海市宜山路600号, 上海交通大学附属第六人民医院消化内科. daqdong@online.sh.cn
电话: 021-64369181-8969 传真: 021-64837019
收稿日期: 2006-11-04 接受日期: 2006-12-01
Effect of H2-receptor blocker combined with domperidone on the blood flow of portal venous system in patients with liver cirrhosis
Wei Da, Jin-Lian Chen, Jin-Shui Zhu, Ni-Wei Chen, Sun Qun, Wei-Xiong Chen
Wei Da, Jin-Lian Chen, Jin-Shui Zhu, Ni-Wei Chen, Sun Qun, Wei-Xiong Chen,Department of Gastroenterology, the Affiliated Sixth People’s Hospital of Shanghai Jiao Tong University, Shanghai 200233, China
Correspondence to:Wei Da, Department of Gastroenterology, the Affiliated Sixth People’s Hospital of Shanghai Jiao Tong University, 600 Yishan Road, Shanghai 200233, China. daqdong@online.sh.cn
Received:2006-11-04 Accepted:2006-12-01
AbstractAIM: To explore the effect of H2-receptor blocker combined with domperidone on the blood flow of portal venous system in patients with liver cirrhosis.
METHODS: A total of 60 patients with liver cirrhosis were randomly and averagely divided into group A, B, and C, treated with H2-receptor blocker, domperidone, and their combination, respectively. Twenty healthy subjects served as normal controls. Portal venous flow (PVF, mL/min), splenic venous flow (SVF, mL/min) and superior mesenteric venous flow (SMVF, mL/min) were determined using Doppler ultrasonography before and after treatment.
RESULTS: After treatment, PVF was significantly higher than that before treatment (850.23 ± 140.78 vs 695.22 ± 221.44, P < 0.01), while SVF and SMVF were lower (both P > 0.05) in group A. PVF was increased as compared with that before treatment in group B, but there was no significant difference (P > 0.05). However, SVF and SMVF were markedly decreased as compared with those before treatment in group B (SVF: 598 ......
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