早期肠内谷氨酰胺补给对烫伤大鼠回肠p-ERK通路的影响
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郭光华, 邓志云, 范 骏, 张红艳, 李国辉
肠内营养;谷氨酰胺;p-ERK1,2;D-乳酸郭光华,邓志云,范骏,张红艳,李国辉.早期肠内谷氨酰胺补给对烫伤大鼠回肠p-ERK通路的影响. 世界华人消化杂志2007;15(4)353-358,郭光华,邓志云,范骏,张红艳,李国辉
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郭光华, 邓志云, 范骏, 张红艳, 李国辉, 南昌大学第一附属医院烧伤中心 江西省南昌市 330006
郭光华, 医学硕士, 教授、主任医师, 博士生导师, 主要从事烧伤方面的研究.江西省自然科学基金项目, No. 0340078
通讯作者: 郭光华, 330006, 江西省南昌市, 南昌大学第一附属医院烧伤中心. guogh2000@hotmail.com
电话: 0971-8692572
收稿日期: 2006-09-09 接受日期: 2006-10-11
Effect of initial enteral glutamine supplementation on p-ERK1/2 pathway in ileal mucosa of scalded rats
Guang-Hua Guo, Zhi-Yun Deng, Jun Fan, Hong-Yan Zhang, Guo-Hui Li
Guang-Hua Guo, Zhi-Yun Deng, Jun Fan, Hong-Yan Zhang Guo-Hui Li, Center of Burn Injury, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
Supported by the Natural Science Foundation of Jiangxi Province, No. 0340078
Correspondence to: Guan-Hua Guo, Center of Burn Injury, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China. guogh2000@hotmail.com
Received: 2006-09-09 Accepted: 2006-10-11
AbstractAIM:To investigate the effect of initial enteral glutamine supplementation on p-ERK1/2 expression in ileal mucosa of scalded rats.
METHODS: Healthy adult Sprague Dawley rats were randomly divided into enteral nutrition (EN) group (n = 40), enteral nutrition plus glutamine (EN + Gln) group (n = 40) and pseudo-scalded (PS) group (n = 8). Scalded model (30% total body surface area, Ⅲ0 scald injury) was established in the rats of the former two groups, and the corresponding methods were used. The expression of p-ERK1/2 in ileal mucosa was analyzed by immunohistochemical staining and Western blot, and the changes of plasma D-lactate concentration in portal vein were measured by ultraviolet spectrophotometry.
RESULTS: The concentration of D-lactate was heightened after scalding, and it restored to the normal level after 48 hours in EN + Gln group, which was significantly lower than that in EN group (4 ......
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