Influence of Dahuang Zhechong Pill on quantification analysis of liver function with scintigraphy in patients with chronic viral hepatitis

    PAN Zhiª²Heng1, CHENG Muª²Hua2, LI Lin1, HE Yiª²Hua1, GUAN Weiª²Bing1, XU Jieª²Hua2, CHEN Yi3

    1Department of Traditional Chinese Medicine, 2Department of Nuclear Medicine£¬ Third Affiliated Hospital, Sun Yatsen Univerª²sity, Guangzhou 510630, China, 3Department of Internal Medicine, Huizhou People¬ðs Hospital, Huizhou 516000, China

    ¡¾Abstract¡¿ AIM: To observe the effect of Dahuang Zhechong Pill (DZP) on the quantification analysis of liver function with scintigraphy in the patients with chronic viral hepatitis and liver cirrhosis. METHODS: Thirtyª²six patients with chronic viral hepatitis and liver cirrhosis were treated with DZP and meanwhile underwent quantification analysis of liver function with scintiª²graphy as well as routine liver function, fibrosis indexes and Bª²mode ultrasound. RESULTS: The peak value (PV), uptake index (UI) and uptake speed index (UsI) in the treatment group were significantly lower than those in the normal control group (18.94¡À6.80 vs 29.67¡À18.98, P<0.01; 10.84¡À5.99 vs 18.41¡À13.87, P<0.05; 0.58¡À0.39 vs 1.23¡À0.81, P<0.01), but the peak time (PT) and mean residence time (MRT) were longer than those in the normal control group (16.83¡À4.89 vs 10.95¡À2.79, P<0.001; 5.93¡À2.96 vs 2.74¡À0.97, P<0.01). And descend speed index (DsI) was lower than that in the normal control group (0.07¡À0.09 vs 0.18¡À0.14, P<0.001). After treatment with DZP for about 6 months, PT, MRT and relative uptake index (RUI) were remarkably improved (9.05¡À2.03 vs 15.45¡À5.16, 2.07¡À0.69 vs 6.11¡À3.19, 3.64¡À1.91 vs 1.62¡À0.85, P<0.01). CONCLUSION: DZP could improve the quantification analysis of liver function with scintigraphy as well as routine liver function, fibrosis indexes and Bª²mode ultrasound in the patients with chronic viral hepatitis and liver cirrhosis. ......