降压药物的疗效分析
高血压病；药物治疗；靶器官损害,,],高血压病；药物治疗；靶器官损害,1对象与方法,2结果,3讨论,[参考文献]
降压药物的疗效分析 (pdf)[摘要] 目的 通过对齐齐哈尔地区高血压患者治疗情况及血压、心、脑、肾、大血管损害情况的2年跟踪调查，观察不同的降压药物对患者降压达标率，靶器官损害程度的影响。
方法 对齐齐哈尔地区200个家庭中2480人进行调查，确诊为高血压病者526例，将526例根据服药情况分为A、B、C三组。对这三组患者血压情况、靶器官损害情况通过心电图、心脏彩超、血脂、肾功等进行评价。
结果 A组在血压控制达标率，保护靶器官方面均优于B、C组，同时，B组恶性事件的发生率又明显低于C组。
结论 降压带来的绝对益处在于血压降低本身，而心肌、血管重构的发生说明高血压只是一个症状，降压不能阻止疾病进展。ACEI、CCB、β受体阻滞剂在降压同时抑制肾素—血管紧张素—醛固酮系统，抑制交感神经兴奋性，抑制血管活性物质的释放，是理想的治疗方案。
[关键词] 高血压病；药物治疗；靶器官损害
Efficacy of antihypertensives
ZHAO Xiaodi,FU Chao,DING Xiujuan,et al.
The First Hospital,Qiqihar 161005,China
[Abstract] Objective To observe the efficacy of different antihypertensives and target organ damage condition in Qiqihar.Methods 2480 cases from 200 families were investigated,526 cases of hypertension comfirmed.526 cases were randomized into A,B and C group in terms of drug use.Blood pressure and damage of target organ were evaluated with EGG,cardiac ultrasound,blood lipid and renal function.The investigation lasted 2 years.Results Blood pressure control and protection of target organ in A group was better than B and C group.Conclusion Combination of ACEI,CCB and β-blocker is ideal to control blood pressure,inhibit activity of sympathetic nerve and vasoactive substances. ......
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