子宫内膜异位症；NFκB；血管内皮生长因子类；免疫组织化学

核转录因子κB和血管内皮生长因子在子宫内膜异位症中的表达及其相关性

http://www.100md.com 《第四军医大学学报》

子宫内膜异位症；NFκB；血管内皮生长因子类；免疫组织化学,,子宫内膜异位症；NFκB；血管内皮生长因子类；免疫组织化学,0引言,1对象和方法,2结果,3讨论,【参考文献】

     Expressions and correlation of nuclear factorkappaB and vascular endothelial growth factor in endometriosis

    WANG Fang, HE YuanLi, ZHAO RuZhu, LIU MuBiao, PENG DongXian

    Department of Gynecology and Obstetrics, Lanzhou General Hospital, Lanzhou Military Area Command, Lanzhou 730050, China, Department of Gynecology and Obstetrics, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China

    【Abstract】AIM: To investigate the expressions of nuclear factorkappaB(NFκB) and vascular endothelial growth factor(VEGF) proteins in endometriosis(EM), and to evaluate the correlation between NFκB and VEGF expressions. METHODS: Immunohistochemistry was used to examine the NFκB and VEGF protein expression in 35 specimens of normal endometrium,48 of eutopic endometrium of endometriosis and 76 of ectopic endometrium, and the results were analyzed with SPSS11.0 statistical software. RESULTS: The expressions of NFκB and VEGF were mainly found in the glandular epithelial cells of the 3 kinds of endometrium, with the ectopic endometriotic tissues showing the highest and the normal endometrium showing the lowest expression (P<0.05). Both NFκB and VEGF expressions in proliferative phase were significantly lower than those in secretory phase of normal and ectopic endometria (P<0.05). Furthermore, the expressions of NFκB and VEGF proteins were positively correlated in normal endometria, eutopic and ectopic endometria (rs=0.660, 0.733 and 0.827, respectively, P<0.01). CONCLUSION: NFκB and VEGF proteins are highly expressed and show a positive correlation in EM, which suggests that they may participate in the pathogenesis of EM. ......

百拇医药网 http://www.100md.com/html/DirDu/2007/02/17/37/48/95.htm

您现在查看是摘要页，全文长 9453 字符。