抑癌基因PTEN及环氧化酶2在大肠癌中的表达及其意义
PTEN;,环氧化酶2;,大肠癌,,],PTEN;,环氧化酶2;,大肠癌,1材料和方法,2结果,3讨论,参考文献:
[摘要] 目的:通过检测抑癌基因PTEN和环氧化酶2(COX2)在大肠癌中的表达,探讨其在大肠癌中的意义。 方法:应用SP法免疫组化方法检测10例正常大肠黏膜、80例大肠癌组织中PTEN和COX2的表达。结果:正常大肠黏膜中PTEN为强阳性表达,在大肠癌中有41.2%为阴性或弱阳性表达,明显低于正常组(P<0.01);COX2在正常大肠黏膜中80%为阴性表达,而在大肠癌中阳性率为72.5%,显著高于正常组的表达(P<0.01);在大肠癌中PTEN和COX2存在负相关(P<0.05)。 结论:抑癌基因PTEN和COX2在大肠癌的发生发展过程中起着重要的作用。[关键词] PTEN; 环氧化酶2; 大肠癌
Expression and Significance of Tumor Suppressor Gene PTEN and Cyclooxygenase2 in Colorectal Cancer
ZHENG Zhaohui, HUANG Yinggui,LIN Hong
(Guangdong Traditional Chinese Medicine Hospital Zhuhai Hospital,Guangdong Zhuhai 519015,China; Affiliated Hospital Of Guangdong Medical College, Zhanjiang, Guangdong 524001, China)
Abstract: Objective To detect the expression of tumor suppressor gene PTEN and cyclooxygenase2 (COX2) in colorectal cancer, and analyze their significance. Methods SP immunohistochemical method was used to detect the expression of PTEN and COX2 in 10 cases of normal colorectal membrane and 80 cases of colorectal cancer. Results The expression of PTEN in all of the normal colorectal membrane were positive ......
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