口服灵芝孢子油对小鼠的扶正及减毒作用研究
灵芝孢子油；,免疫,；,环磷酰胺,,灵芝孢子油；,免疫,；,环磷酰胺,1材料,2方法,3结果,4讨论,参考文献：
摘要：目的观察灵芝孢子油的扶正减毒作用。方法以正常和 H22荷瘤小鼠为对象，通过检测外周血 WBC数、骨髓有核细胞数、脾脏指数、胸腺指数来观察口服灵芝孢子油(2.5，1.25，0.625 g/kg)对于环磷酰胺(Cy)化疗及60Co放疗的减毒作用；通过小鼠碳廓清实验、血清溶血素测定实验检测药物对 H22荷瘤小鼠免疫功能的影响。结果灵芝孢子油中高剂量组均可明显对抗由大剂量Cy、60Co照射造成的正常及荷瘤小鼠外周血WBC,骨髓有核细胞数，脾脏指数和胸腺指数下降 (P<0.01, P<0.05)。灵芝孢子油各剂量均可显著提高荷瘤小鼠吞噬系数α，中高剂量组可明显提高荷瘤小鼠的血清半数溶血值(P<0.01,P<0.05)。结论灵芝孢子油可减低 Cy和 60Co所致的骨髓抑制毒性，并可显著提高小鼠细胞和体液免疫功能。关键词：灵芝孢子油； 免疫 ； 环磷酰胺
Effect of Ganoderma lucidum Spores Oil on Reducing the Toxicity of Radiochemotherapy and Enhancing the Function of Immune System in Mice
LIU Juyan, JIN Ling, JIANG Zhaojian
(Medical College, Jinan University, Guangzhou 510632, China; Guangzhou Pharmaceutical Holdings Ltd., Guangzhou 510130, China)
Abstract：ObjectiveTo study the effects of G. lucidum spores oil on reducing the toxicity of the radiochemotherapy and enhancing the function of immune system in mice. Methods Study the effect of G. lucidum spores oil (at the dose of 2.5，1.25，0.725 g/kg) on reducing the toxicity of the Cy chemotherapy and 60Co radiotherapy by detecting the number of the peripheral blood leucocyte, the number of bone marrow karyota;spleen index, thymus index of normal mice and H22-bearing mice by carbon clearance test and serum erythrocytolysin test. Results It showed that G. lucidum spores oil at high (2.5 g/kg) and middle dose (1.25 g/kg) could significantly relieve the decrease of the number of the peripheral blood leucocyte, the number of bone marrow karyota, spleen index and thymus index of normal mice and tumopbearing mice by Cy at a high dose and 60Co (P<0.01, P<0.05). G. lucidum spores oil at each dose could significantly increase macrophage phagocytic index; and at high and middle dose it can significantly enhance the serum erythrocytolysin level of H22-bearing mice (P<0.01, P<0.05).ConclusionG. lucidum spores oil could relieve the myelosuppression caused by Cy and 60 Co; enhance the cellular and humoral immune function of tumor H22-bearing mice. ......
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