连续性血液净化治疗热射病并发多脏器功能不全综合征的临床分析
持续性血液净化；热射病；多脏器功能不全综合征；细胞因子,,],持续性血液净化；热射病；多脏器功能不全综合征；细胞因子,1资料与方法,2结果,3讨论,[参考文献]
[摘要] 目的 分析连续性血液净化(CBP)技术在热射病并发多脏器功能不全综合征(MODS)患者救治中的作用。方法 对2例热射病合并MODS患者采用Baxter BM25机器行CBP治疗24次，在每次CBP治疗前及治疗后2 h、4 h、8 h分别取血样，采用ELISA法检测肿瘤坏死因子(TNF-α)、白细胞介素-1(IL-1)、白细胞介素-8(IL-8)的含量，并分别于治疗前与治疗后即时取血化验肌酐(SCr)、尿素氮(BUN)、总胆红素(TBIL)、血肌红蛋白(bMb)浓度。结果 2例患者24次CBP后血浆TNF-α、IL-1、IL-8水平均明显下降(P<0.05)，血清BUN、SCr、bMb、TBIL均有不同程度降低(P<0.05或<0.01)。 结论 CBP能清除热射病并发MODS患者血浆中的细胞因子，并可以改善肝、肾功能指标，有效阻止MODS的进展。[关键词] 持续性血液净化；热射病；多脏器功能不全综合征；细胞因子
Clinic analysis of heartstroke associated with multiple organ dysfunction syndrome treated by continuous blood purification
HE Junfeng,GAO Juping,LI Bing.Department of ICU,the Affiliated Hospital of Medical College,Qingdao University,Qingdao 266071,China
[Abstract] Objective To analyze the role of continuous blood purification(CBP) in treatment of heartstroke associated with multiple organ dysfunction syndrome(MODS). Methods 2 patients met heartstroke associated with MODS were treated 24 times with Baxter BM25 CBP.The plasma TNF-α,IL-1,IL-8 were measured by ELISA at 0,2,4,8h following CBP,and the levels of Bun,SCr,totle Bil,blood Mb. Results The plasma concentrations of TNF-α,IL-1,IL-8 decreased actually(P<0.05).The levels of Bun,SCr,totle Bil,blood Mb descended at the different extent(P<0.05 or <0.01).Conclusion CBP can remove many inflammatory cytokines in plasma,and improve the function markers of liver and kidney in the patients met heartstroke associated with MODS. ......
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