β细辛醚平喘作用的药效学研究
β细辛醚;,支气管哮喘,,β细辛醚;,支气管哮喘,1材料与方法,2结果,3讨论,参考文献:
摘要:目的探讨β细辛醚的平喘作用。方法豚鼠随机分成β细辛醚高、中、低剂量组、阳性药物组(离体实验为氨茶碱,整体实验为地塞米松)和模型空白对照组,以豚鼠离体气管片实验和卵蛋白喷雾致喘整体实验,研究β细辛醚的平喘作用。结果β细辛醚可直接舒张豚鼠离体气管平滑肌;对整体哮喘模型,β细辛醚能延长哮喘发作的潜伏时间,减轻症状发作的严重程度。结论β细辛醚有平喘作用。关键词:β细辛醚; 支气管哮喘
Study on the Effect of βasarone on Bronchial Asthma
SHI Chen, FANG Yongqi
(The Central Laboratory of The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou,510405, China)
Abstract:ObjectiveTo study on the effect of βasarone on bronchial asthma. MethodsThe Guinea pigs were randomly divided into five groups: βasarone of high dose, βasarone of moderate dose, βasarone of low dose, aminophylline in vitro or dexamethasone in vivo, and control. Adopted the Guinea pig's tracheal slice test in vitro and ovalbumin-induced asthma test in vivo respectively to study the effect of β-asarone on bronchial asthma. Results βasarone with all three doses showed the effect of the relaxation of the contractive tracheal slices in vitro, and the prolongation of the asthma delitescence, mitigate the serious extent of symptoms of asthma in vivo. Conclusionβasarone has positive effect on bronchial asthma. ......
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