Treatment of delayed graft function in renal transplantation (report of 14 cases)

    Feng Zhenhua, Ding Yongquan

    (Department of Urology, the Municipal Hospital of Gaozhou, Gaozhou 525200, China)

    ABSTRACT: Objective To investigate the cause and treatment for delayed graft function (DGF) in renal transplantation. Methods Among 14 cases of DGF, one was diagnosed as renal vein embolism, two as nephrotoxicity caused by CsA, six as acute tubular necrosis (ATN) and five as acute rejection (AR). The diagnoses were confirmed by clinical presentation, blood creatinine, color Doppler ultrasonography, and fine needle asperation biopsy (FNAB), etc. All cases were individually treated with hemodialysis, surgical exploration and the adjustment of immunosuppressant. Results In 13 cases, urinary output has been increased 9 to 27 days after the operation and renal function recovered one month after operation. One case underwent nephrectomy because of renal venous embolism. Conclusion The cause of DGF included surgical complications, nephrotoxicity caused by CsA, ATN and AR. It should be diagnosed early on clinical presentation and assistant examination, and treated with hemodialysis, surgical exploration and the adjustment of immunosuppressant with satisfactory results. ......