姜桂pH依赖型梯度释药胶囊的研究
复方中药;,pH依赖型梯度释药系统;,姜桂胶囊,,复方中药;,pH依赖型梯度释药系统;,姜桂胶囊,1试剂与仪器,2方法与结果,3讨论,参考文献:
摘要:目的制备姜桂pH依赖型梯度释药胶囊并进行释放度考察。方法分别以 HPMC,EudragitL10055和Eudragit L100为包衣材料制备pH依赖型梯度释药微丸后制成胶囊,并进行体外释放度研究。结果所制备的3批胶囊的pH分别在1.0,5.5和6.8梯度释药,指标成分桂皮醛和二苯基庚烷A释放度的f 2值分别为72.1,69.3和73.9。结论缓释胶囊中桂皮醛和二苯基庚烷A能同步释放,具有pH依赖型释药的特征。关键词:复方中药; pH依赖型梯度释药系统; 姜桂胶囊
Studies on JiangGui pH Dependent Gradient-release Capsules
L Zhufen, FENG Yifan, HUANG Yu, CAI Jiancong, SHEN Lou, GUO Xiaoling, MENG Qing, XIE Qingchun
(Institute of Materia Medica, Guangdong College of Pharmacy, Guangzhou 510240,China; Shenzhen East Tiger Biological Medicine Co., Ltd.,Shenzhen 518000,China)
Abstract:ObjectiveTo prepare JiangGui pH dependent gradientrelease capsules and investigate the drug release. MethodsThe pH dependent gradient-release capsules were prepared by three pellets which coated with HPMC, Eudragit L10055 and Eudragit L100. The release profile of the pH dependent gradientrelease system was determined in vitro. ResultsThe result showed that the release of cinnamldehyde and diarylheptanoid A from capsules complied with the simulated gastrointestinal pH conditions.The f 2 value of release profile of cinnamldehyde and diarylheptanoid A were similar.ConclusionThe cinnamldehyde and diarylheptanoid A from pH dependent gradientrelease capsules can release simultaneously, and the capsules haue the characteristics of pH dependent gradientrelease in gastrointestinal tract. ......
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