关键词 肾素-血管紧张素-醛固酮系统；胺碘酮；心房颤动

    摘要 目的 研究不同肾素、血管紧张素和醛固酮水平与心房颤动转律效果的关系。方法 对持续性心房颤动患者，在使用胺碘酮转律后依转律效果分为转律成功组(n=17)和转律未成功组(n=19)，比较二组患者血浆肾素、血管紧张素和醛固酮浓度的不同。进一步分析其浓度水平与左心房大小的相关性。结果 在转律未成功组患者血浆肾素、血管紧张素和醛固酮水平显著高于转律成功组(P<0.001、P<0.05、P<0.05)；血浆肾素、血管紧张素和醛固酮水平与左心房直径呈显著正相关(P<0.001)。结论 肾素、血管紧张素和醛固酮系统的激活对心房颤动的发生、维持和终止起重要作用。加用血管紧张素转换酶抑制剂可能改善心房颤动患者的转律效果。

    EFFECT OF RENIN-ANGIOTENSIN-ALDOSTERONE LEVELS ON SINUS RHYTHM OF PATIENTS WITH PERSISTENT ATRIAL FIBRILLATION

    Jia Xinwei,Di Pifan,Cao Yanxia.

    The Affiliated Hospital of Hebei University,Baoding 071000,China

    Key words renin-angiotensin-aldosterone system； amiodarone； atrial fibrillation

    Abstract Objective To approach relationship of renin-angiotensin-aldosterone levels and amiodarone reversing sinus rhythm of patients with persistent atrial fibrillation. Methods According to results of amiodarone reversing their sinus rhythm, 36 patients with persistent atrial fibrillation were divided into two groups, which were successful group(n=19) and unsuccessful group(n=17). Serum levels of renin-angiotensin-aldosterone in the two groups were compared and their correlation with left atrium diameter were also studied. Results The levels of renin, angiotensin and aldosterone in unsuccessful group were significantly higher than that of successful group (P<0.001,P<0.05,and P<0.05 respectively). The levels of renin, angiotensin and aldosterone correlated significantly to diameter of left atrium (P<0.001). Conclusion Our results indicate that renin-angiotensin-aldosterone system play an important role in the initiation, maintenance and termination of atrial fibrillation. Our results also suggest that angiotensin-converting enzyme inhibitors might facilitate rebuilding of the sinus rhythm in patients with persistent atrial fibrillation. ...... 濠碘€冲€归悘澶愬箖閵娿儲韬ù锝堟硶閺併倝骞嶇€ｎ偅绨氱紒娑橆槹缁侊妇鎲撮崼鐔割槯闁哄啰濮电涵鍫曞蓟閵壯勭畽闁瑰瓨鐗旂粭鍛姜閽樺寮块柡鍌氭祫缁辨繈宕ｉ婵嗗幋闁哄嫷鍨甸～锕傚箹濠婂懎鍋嶇€殿喗娲橀幖鍛婂緞鏉堚晜鍩傞柍銉︾矎濞村棝鎯嶆担娴嬪亾濠垫挾绀夐悹鍥棑閸嬶綁宕欑拠鑼綄妤犵偞娲樺〒鑸电▔鐎ｎ偅鐓欓柣銊ュ閳ь剚绮庨弫鎼佹嚇閹寸姴顣奸柍銉︾箖閸ㄣ劑鍨惧⿰鍐ㄦ枾缂傚啯鍨块妴澶愬灳濠靛⿴鍟忛梻鍌ゅ枔閳ь剨鎷�


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