幽门螺杆菌感染胃癌组织MMP-2和MMP-9表达及其对胃癌侵袭转移能力的影响
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王 舰, 李胜军, 赵成海, 罗恩杰
幽门螺杆菌;胃癌;基质金属蛋白酶-9;基质金属蛋白酶-2;免疫组化,王舰,李胜军,赵成海,罗恩杰,通讯作者:,Expressionofmatrixmetalloproteinase-2andmatrixm
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王舰, 中国医科大学口腔医学院 辽宁省沈阳市 110002
李胜军, 中国医科大学基础医学院免疫学教研室 辽宁省沈阳市 110001
赵成海, 中国医科大学基础医学院病理生理教研室 辽宁省沈阳市 110001
罗恩杰, 中国医科大学基础医学院病原生物学教研室 辽宁省沈阳市 110001
通讯作者: 王舰, 110002, 辽宁省沈阳市和平区南京北街117号, 中国医科大学口腔医学院. wangjcmu@sina.com
电话: 024-22892645
收稿日期: 2006-12-11 接受日期: 2007-01-10
Expression of matrix metalloproteinase-2 and matrix metalloproteinase-9 in H pylori-infected gastric cancer tissues and their effects on the invasion and metastasis of gastric cancer
Jian Wang, Sheng-Jun Li, Cheng-Hai Zhao, En-Jie Luo
Jian Wang,School of Stomatology, China Medical University, Shenyang 110002, Liaoning Province, China
Sheng-Jun Li,Department of Immunology, China Medical University, Shenyang 110001, Liaoning Province, China
Cheng-Hai Zhao,Department of Pathophysiology, China Medical University, Shenyang 110001, Liaoning Province, China
En-Jie Luo,Department of Pathogenic Biology, China Medical University, Shenyang 110001, Liaoning Province, China
Correspondence to:Jian Wang, School of Stomatology, China Medical University, 117 Nanjing North Street, Heping District, Shenyang 110002, Liaoning Province, China. wangjcmu@sina.com
Received:2006-12-11 Accepted: 2007-01-10
Abstract
AIM: To detect the expression of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) in gastric tissues withH pylori infection, and to analyze the effect of H pylori infection on the invasion and metastasis of gastric cancer.
METHODS: A total of 42 cases of gastric cancer specimens were included in this study. H pylori infection was determined by improved Giemsa method and the expression of MMP-2 and MMP-9 were detected by immunohistochemistry. Fisher’s exact was used to analyze the correlation between H pylori infection and the clinical pathological features of gastric cancer.
RESULTS: H pylori infection was confirmed in 26 of 42 cases, and it was correlated with the staging and lymph node metastasis, but not with the sex, age of patients and histological types. H pylori infection was also significantly correlated with the expression of MMP-9 and MMP-2 (χ2 = 7.77, P < 0.01; χ2 = 8.08, P < 0.01).
CONCLUSION: H pylori infection may promote the invasion and metastasis of gastric cancer by increasing the expression of MMP-2 and MMP-9.
Key Words: H pylori; Gastric cancer; Matrix metalloproteinase-2; Matrix metalloproteinase-9; Immunohistochemistry
Wang J, Li SJ, Zhao CH, Luo EJ. Expression of matrix metalloproteinase-2 and matrix metalloproteinase-9 in H pylori-infected gastric cancer tissues and their effects on the invasion and metastasis of gastric cancer. Shijie Huaren Xiaohua Zazhi 2007;15(7):755-757
摘要
目的: 分析幽门螺杆菌感染对胃癌转移侵袭能力的影响, 同时对其基质金属蛋白酶2(MMP-2)和基质金属蛋白酶9(MMP-9)表达情况进行检测.
方法: 采用改良的Giemsa法检测幽门螺杆菌感染, 免疫组化法检测42例胃癌标本MMP-9和MMP-2表达情况 ......
王舰, 中国医科大学口腔医学院 辽宁省沈阳市 110002
李胜军, 中国医科大学基础医学院免疫学教研室 辽宁省沈阳市 110001
赵成海, 中国医科大学基础医学院病理生理教研室 辽宁省沈阳市 110001
罗恩杰, 中国医科大学基础医学院病原生物学教研室 辽宁省沈阳市 110001
通讯作者: 王舰, 110002, 辽宁省沈阳市和平区南京北街117号, 中国医科大学口腔医学院. wangjcmu@sina.com
电话: 024-22892645
收稿日期: 2006-12-11 接受日期: 2007-01-10
Expression of matrix metalloproteinase-2 and matrix metalloproteinase-9 in H pylori-infected gastric cancer tissues and their effects on the invasion and metastasis of gastric cancer
Jian Wang, Sheng-Jun Li, Cheng-Hai Zhao, En-Jie Luo
Jian Wang,School of Stomatology, China Medical University, Shenyang 110002, Liaoning Province, China
Sheng-Jun Li,Department of Immunology, China Medical University, Shenyang 110001, Liaoning Province, China
Cheng-Hai Zhao,Department of Pathophysiology, China Medical University, Shenyang 110001, Liaoning Province, China
En-Jie Luo,Department of Pathogenic Biology, China Medical University, Shenyang 110001, Liaoning Province, China
Correspondence to:Jian Wang, School of Stomatology, China Medical University, 117 Nanjing North Street, Heping District, Shenyang 110002, Liaoning Province, China. wangjcmu@sina.com
Received:2006-12-11 Accepted: 2007-01-10
Abstract
AIM: To detect the expression of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) in gastric tissues withH pylori infection, and to analyze the effect of H pylori infection on the invasion and metastasis of gastric cancer.
METHODS: A total of 42 cases of gastric cancer specimens were included in this study. H pylori infection was determined by improved Giemsa method and the expression of MMP-2 and MMP-9 were detected by immunohistochemistry. Fisher’s exact was used to analyze the correlation between H pylori infection and the clinical pathological features of gastric cancer.
RESULTS: H pylori infection was confirmed in 26 of 42 cases, and it was correlated with the staging and lymph node metastasis, but not with the sex, age of patients and histological types. H pylori infection was also significantly correlated with the expression of MMP-9 and MMP-2 (χ2 = 7.77, P < 0.01; χ2 = 8.08, P < 0.01).
CONCLUSION: H pylori infection may promote the invasion and metastasis of gastric cancer by increasing the expression of MMP-2 and MMP-9.
Key Words: H pylori; Gastric cancer; Matrix metalloproteinase-2; Matrix metalloproteinase-9; Immunohistochemistry
Wang J, Li SJ, Zhao CH, Luo EJ. Expression of matrix metalloproteinase-2 and matrix metalloproteinase-9 in H pylori-infected gastric cancer tissues and their effects on the invasion and metastasis of gastric cancer. Shijie Huaren Xiaohua Zazhi 2007;15(7):755-757
摘要
目的: 分析幽门螺杆菌感染对胃癌转移侵袭能力的影响, 同时对其基质金属蛋白酶2(MMP-2)和基质金属蛋白酶9(MMP-9)表达情况进行检测.
方法: 采用改良的Giemsa法检测幽门螺杆菌感染, 免疫组化法检测42例胃癌标本MMP-9和MMP-2表达情况 ......
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