MAGE-A1在食管癌中的表达及其与肿瘤细胞增殖的关系
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李 佳, 潘林娜, 张志燕, 李 曼
黑色素瘤抗原基因A1;Ki-67;增殖;免疫;食管癌,李佳,潘林娜,张志燕,李曼,李佳,通讯作者:,ExpressionofmelanomaantigenA1anditsrelationshipwithtumorcellprolifer
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李佳, 潘林娜, 张志燕, 李曼, 哈尔滨医科大学附属肿瘤医院腔镜室 黑龙江省哈尔滨市 150040
李佳, 硕士, 住院医师, 主要从事食管癌与黑色素瘤抗原家族方面的研究.
通讯作者: 潘林娜, 150040, 黑龙江省哈尔滨市南岗区哈平路150号, 哈尔滨医科大学附属肿瘤医院腔镜室.
limanl2488@hotmail.com
电话: 0451-82081615 传真: 0451-86663760
收稿日期: 2006-12-11 接受日期: 2007-01-18
Expression of melanoma antigen A1 and its relationship with tumor cell proliferation in esophageal carcinoma
Jia Li, Lin-Na Pan, Zhi-Yan Zhang, Man Li
Jia Li, Lin-Na Pan, Zhi-yan Zhang, Man Li,Department of Endoscopy, the Affiliated Cancer Hospital of Harbin Medical University, Harbin 150040, Heilongjiang Province, China
Correspondence to:Lin-Na Pan, Department of Endoscopy, the Affiliated Cancer Hospital of Harbin Medical University, Harbin 150040, Heilongjiang Province, China. limanl2488@hotmail.com
Received: 2006-12-11 Accepted:2007-01-18
Abstract
AIM: To investigate the expression of melanoma antigen A1 (MAGE-A1) and Ki-67 in esophageal cancer (EC) and their correlations with the clinical pathological features and survival time of EC patients.
METHODS: The expression of MAGE-A1 and Ki-67 was detected by SP immunohistochemical technique using mouse anti-human MAGE-A1 and Ki-67 antibodies in formalin-fixed and paraffin-embedded sections from 60 EC patients.
RESULTS: The positive rate of MAGE-A1 expression was 83.3% (50/60) in EC, with a high expression rate of 10% (6/60) and low expression rate of 73.3% (44/60), while the positive rate of MAGE-A1 expression was 0% in the normal esophageal tissues, significantly lower than that in EC tissues (P < 0.001). The positive rate of Ki-67 expression was 93.3% (56/60) in EC, with a high expression rate of 70% (42/60) and low expression rate of 23.3% (14/60), while the positive rate of Ki-67 expression was 13.3% (4/30) in esophageal normal tissues, significantly lower than that in EC tissues (P < 0.001). There was a negative correlations between the positive expression of MAGE-A1 and Ki-67 (r = -2.91, P < 0.05). Besides, MAGE-A1 expression was also correlated with the differentiation degrees of carcinoma (P < 0.05), and Ki-67 expression was correlated with the age of patients, differentiation degrees and pathological type of carcinoma (P < 0.05). The survival time was higher for patients with the positive expression of MAGE-A1 than that for patients with the negative MAGE-A1 expression (P < 0.05).
CONCLUSION: MAGE-A1 is highly expressed in EC patients, which is correlated with the proliferation of tumor cells. The patients with positive MAGE-A1 expression have a favorable prognosis.
Key Words: Melanoma antigen A1; Ki-67; Proliferation; Immunology; Esophageal cancer
Li J, Pan LN, Zhang ZY, Li M. Expression of melanoma antigen A1 and its relationship with tumor cell proliferation in esophageal carcinoma. Shijie Huaren Xiaohua Zazhi 2007;15(7):706-711
摘要
目的: 研究食管癌中肿瘤特异性抗原MAGE-A1, Ki-67的表达及其相关性, 探讨他们与食管癌生物学行为及生存时间的关系 ......
李佳, 潘林娜, 张志燕, 李曼, 哈尔滨医科大学附属肿瘤医院腔镜室 黑龙江省哈尔滨市 150040
李佳, 硕士, 住院医师, 主要从事食管癌与黑色素瘤抗原家族方面的研究.
通讯作者: 潘林娜, 150040, 黑龙江省哈尔滨市南岗区哈平路150号, 哈尔滨医科大学附属肿瘤医院腔镜室.
limanl2488@hotmail.com
电话: 0451-82081615 传真: 0451-86663760
收稿日期: 2006-12-11 接受日期: 2007-01-18
Expression of melanoma antigen A1 and its relationship with tumor cell proliferation in esophageal carcinoma
Jia Li, Lin-Na Pan, Zhi-Yan Zhang, Man Li
Jia Li, Lin-Na Pan, Zhi-yan Zhang, Man Li,Department of Endoscopy, the Affiliated Cancer Hospital of Harbin Medical University, Harbin 150040, Heilongjiang Province, China
Correspondence to:Lin-Na Pan, Department of Endoscopy, the Affiliated Cancer Hospital of Harbin Medical University, Harbin 150040, Heilongjiang Province, China. limanl2488@hotmail.com
Received: 2006-12-11 Accepted:2007-01-18
Abstract
AIM: To investigate the expression of melanoma antigen A1 (MAGE-A1) and Ki-67 in esophageal cancer (EC) and their correlations with the clinical pathological features and survival time of EC patients.
METHODS: The expression of MAGE-A1 and Ki-67 was detected by SP immunohistochemical technique using mouse anti-human MAGE-A1 and Ki-67 antibodies in formalin-fixed and paraffin-embedded sections from 60 EC patients.
RESULTS: The positive rate of MAGE-A1 expression was 83.3% (50/60) in EC, with a high expression rate of 10% (6/60) and low expression rate of 73.3% (44/60), while the positive rate of MAGE-A1 expression was 0% in the normal esophageal tissues, significantly lower than that in EC tissues (P < 0.001). The positive rate of Ki-67 expression was 93.3% (56/60) in EC, with a high expression rate of 70% (42/60) and low expression rate of 23.3% (14/60), while the positive rate of Ki-67 expression was 13.3% (4/30) in esophageal normal tissues, significantly lower than that in EC tissues (P < 0.001). There was a negative correlations between the positive expression of MAGE-A1 and Ki-67 (r = -2.91, P < 0.05). Besides, MAGE-A1 expression was also correlated with the differentiation degrees of carcinoma (P < 0.05), and Ki-67 expression was correlated with the age of patients, differentiation degrees and pathological type of carcinoma (P < 0.05). The survival time was higher for patients with the positive expression of MAGE-A1 than that for patients with the negative MAGE-A1 expression (P < 0.05).
CONCLUSION: MAGE-A1 is highly expressed in EC patients, which is correlated with the proliferation of tumor cells. The patients with positive MAGE-A1 expression have a favorable prognosis.
Key Words: Melanoma antigen A1; Ki-67; Proliferation; Immunology; Esophageal cancer
Li J, Pan LN, Zhang ZY, Li M. Expression of melanoma antigen A1 and its relationship with tumor cell proliferation in esophageal carcinoma. Shijie Huaren Xiaohua Zazhi 2007;15(7):706-711
摘要
目的: 研究食管癌中肿瘤特异性抗原MAGE-A1, Ki-67的表达及其相关性, 探讨他们与食管癌生物学行为及生存时间的关系 ......
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