【摘要】目的观察早期运用亚低温及机械通气治疗重型弥漫性轴索损伤的疗效。方法将140例重型弥漫性轴索损伤患者伤后24 h内分成常温组(34例)、亚低温组(42例)、亚低温结合机械通气组(64例)进行治疗。伤后3个月采用格拉斯哥(GOS)进行疗效分析。结果常温组死亡16例(47.5%)，亚低温组死亡14例(33.3%)，亚低温+机械通气组死亡19例(29.7%)，3组间比较差异有显著意义(P<0.05)，3组呼吸、心率及血气分析各项指标差异有显著意义(P<0.05)。结论采用亚低温结合机械通气治疗可明显改善重型弥漫性轴索损伤病情，提高恢复生存质量，降低残死率。

    【关键词】亚低温；机械通气；重型弥漫性轴索损伤

    Severe diffuse axonal injury treated by combination of hypothermia and artificial ventilationCHEN Junmin,TAO Ximin,XU Guoqiang,et al.Neurosurgical Department,People's Hospital of Qingyuan City,Qingyuan511518,China

    【Abstract】ObjectiveTo observe the clinical effect of severe diffuse axonal injury (DAI) treated by combination of hypothermia and artificial ventilation.Methods140 DAI patients admitted within 24 hours were divided into 3 groups:room temperature group, hypothermia group and hypothermia combined with artificial ventilation group.ResultsAll patients were evaluated by Glasgow Outcome Scale after 3 months. The results showed a significant statistical difference among these groups.ConclusionHypothermia combined with artificial ventilation can improve clinical effect of DAI,increase the quality of life and decrease the mortality. ......