通心络对不稳定型心绞痛患者可溶性细胞间黏附分子1水平的影响
通心络;不稳定型心绞痛;细胞间黏附分子1,,通心络;不稳定型心绞痛;细胞间黏附分子1,1资料与方法,2结果,3讨论,参考文献
【摘 要】 目的 观察通心络对不稳定型心绞痛患者血清可溶性细胞间黏附分子1(sICAM1)水平的影响,探讨其治疗动脉粥样硬化性疾病的可能机制。方法 将60例不稳定型心绞痛患者随机分为常规治疗组(30例)和通心络组(30例),常规治疗组予常规治疗,通心络组在常规治疗的基础上加用通心络。监测治疗前后血清 sICAM1和血浆血脂水平的变化。结果 2组治疗后血浆总胆固醇(TC)和低密度脂蛋白(LDLC)水平均较治疗前明显下降(P<0.05),但2组间比较差异无显著意义;2组甘油三酯(TG)治疗后均下降,高密度脂蛋白胆固醇(HDLC)治疗后均升高,但治疗前后比较差异均无显著意义(P>0.05)。通心络组血清sICAM1水平由治疗前的(129.37±32.29)ng/ml下降到治疗后的(78.42±26.42)ng/ml,常规治疗组血清sICAM1水平由治疗前的(122.32±36.12)ng/ml下降到治疗后的(89.24±21.25)ng/ml,治疗后均有明显降低,且治疗后通心络组sICAM1水平明显低于同期常规治疗组(均P<0.05)。结论 通心络能明显降低不稳定型心绞痛患者血清sICAM1含量,具有抑制动脉血管壁炎症、保护血管内皮细胞的作用。【关键词】 通心络;不稳定型心绞痛;细胞间黏附分子1
Effect of Tongxinluo capsule on intercellular adhesion molecule1 in patients with unstable angina pectoris YE Dahua,XIE Yiqin.Longchuan County Hospital of Traditional Chinese Medicine,Guangdong,Longchuan 517300,China【Abstract】 Objective To observe the effect of Tongxinluo on soluble intercellular adhesion molecule1 (sICAM1) in patients with unstable angina pectoris.Methods 60 cases with unstable angina pectoris were randomly divided into treatment group (n=30,routine treatment added Tongxinluo) and control group (n=30,routine treatment).Before and after 1 month's treatment,sICAM1 in serum and blood lipids were measured.Results After treatment ......
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