Detecion of sIgE, tryptase, IL8, IL12, and eotaxin in plasma of patients with pollinosis in summer or autumn and their clinical implications

    YAO QiJian, HE ShaoHeng, LIN XiaoPing

    Institute of Allergy & Inflammation, Medical College, Shantou University, Shantou 515031, China, Room of Allergy, PLA Center for Diagnosis and Treatment of Respiratory and Allergic Diseases, General Hospital of Shenyang Military Area Command, Shenyang 110016, China

    【Abstract】 AIM：To investigate the correlations between plasma levels of tryptase, interleukin8 (IL8), interleukin12 (IL12) and eotaxin in the patients with grass pollinosis in summer and autumn and their clinical significances. METHODS：A total of 37 patients with grass pollinosis and 23 healthy controls were recruited into the study. Plasma tryptase levels were determined by Unicap Tryptase fluoroimmunoassay. The levels of IL8, IL12 and eotaxin were detected by double sandwich ELISA method. RESULTS：The plasma level of IL8 was significantly increased in the patients with pollinosis as compared with healthy controls (t=2.56, P<0.05). In contrast, the plasma level of IL12 was significantly decreased in the patients with pollinosis as compared with the healthy controls (P<0.05). But the levels of tryptase and eotaxin had no significant differences between the patients and the volunteers (P>0.05). The significant correlations were only between IL8 and IL12 (P<0.01) and between IL8 and eotaxin (P<0.05). CONLUSION: Occurrence of pollinosis is related to many inflammatory cells including mast cells and inflammatory mediators. The downregulation of Th1 cytokines may contribute to the pathogenesis of pollinosis. ...... 婵″倹鐏夐幃銊ユ躬娴ｈ法鏁ら幍瀣簚缁涘绁︾憴鍫熸閺冪姵纭堕弻銉ф箙閹存牔绗呮潪钘夊弿閺傚浄绱濋崣顖濆厴閺勵垵顫﹂幖婊呭偍瀵洘鎼告径杈╂埂閳ユ粏娴嗛惍浣测偓婵撶礉鐠囬鍋ｉ崙璇茬潌楠炴洘娓舵稉瀣煙閻ㄥ嫧鈧粎鏁搁懘鎴犲閳ユ繃鍨ㄩ垾婊冨斧缂冩垿銆夐垾婵婎問闂傤喓鈧拷


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