联合应用埃索美拉唑、铝碳酸镁和莫沙比利治疗难治性胃食管反流病
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王战波, 陈玲玲, 游旭东
胃食管反流病;埃索美拉唑;铝碳酸镁;莫沙比利,王战波,陈玲玲,游旭东,通讯作者:,电话:,收稿日期:,接受日期:,Efficacyofesomeprazolecombinedwithhydrotalciteandmosaprid
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王战波, 陈玲玲, 游旭东, 河南平顶山煤业集团总医院消化内科, 河南省平顶山市 467000
通讯作者: 王战波, 467000, 河南省平顶山市, 河南平顶山煤业集团总医院消化内科. guogh2000@hotmail.com
电话: 0375-2729334
收稿日期: 2006-12-10 接受日期: 2006-12-27
Efficacy of esomeprazole combined with hydrotalcite and mosapride in treatment of refractory gastroesophageal reflux disease
Zhan-Bo Wang, Ling-Ling Chen, Xu-Dong You
Zhan-Bo Wang, Ling-Ling Chen, Xu-Dong You,Department of Gastroenterology, General Hospital of Pingdingshan Coal Group, Pingdingshan 467000, He’nan Province, China
Correspondence to:Zhan-Bo Wang, Department of Gastroenterology, General Hospital of Pingdingshan Coal Group, Pingdingshan 467000, Henan Province, China. guogh2000@hotmail.com
Received:2006-12-10 Accepted:2006-12-27
Abstract
AIM:To evaluate the effect of esomeprazole combined with hydrotalcite and mosapride on refractory gastroesophageal reflux disease (rGERD).
METHODS: A total of 101 rGERD patients were randomly divided into groups A (n = 36), B B (n = 34) and C (n = 31), treated with esomeprazole plus hydrotalcite plus mosapride, esomeprazole plus mosapride, and hydrotacite plus mosapride, respectively. The clinical outcomes were observed and analyzed after 4 and 8 weeks of treatment. Endoscopy was performed to evaluate the effective rate in the three groups.
RESULTS: After 4 weeks of treatment, the total improvement rate was significantly higher in group A (88.9%) than that in group B (79.4%) and C (61.3%) (χ2 = 7.3531, P < 0.05). Eight weeks after treatment, the total improvement rates were 97.2%, 88.2% and 71.0% in group A, B and C, ,and the effective rates detected by endoscopy were 94.4%, 85.3% and 67.7%, respectively. The total improvement rate (χ2 = 9.6039, P < 0.01) and effective rate (χ2 = 8.6496, P < 0.05) were markedly higher in group A than those in B and C group.
CONCLUSION: Esomeprazole combined with hydrotalcite and mosapride may be highly effective in the treatment of rGERD.
Key Words: Gastroesophageal reflux disease; Esomeprazole; Hydrotalcite; Mosapride
Wang ZB, Chen LL, You XD. Efficacy of esomeprazole combined with hydrotalcite and mosapride in treatment of refractory gastroesophageal reflux disease. Shijie Huaren Xiaohua Zazhi 2007;15(8):901-904
摘要
目的: 探讨联合应用埃索美拉唑、铝碳酸镁和莫沙比利治疗难治性胃食管反流病 (r-GERD)的临床疗效.
方法: 101例rGERD患者随机为A (n = 36), B (n = 34)和C组(n = 31), 分别采用埃索美拉唑+铝碳酸镁+莫沙比利、埃索美拉唑+莫沙比利及铝碳酸镁+莫沙比利治疗. 4及8 wk后评价临床症状, 8 wk后评价内镜下有效率.
结果: 治疗4 wk后, A, B和C组临床症状总改善率分别为88.9%, 79.4%和61.3%, A组与B, C两组相比差异显著(χ2 = 7.3531, P<0.05). 治疗8 wk后, A, B和C组临床症状总改善率分别为97.2%, 88.2%和71.0%, 内镜下有效率分别为94.4%, 85.3%和67.7%, A组临床症状总改善率和内镜下有效率与B, C组相比存在显著性差异(χ2 = 9.6079, P<0.01; χ2 = 8.6496, P<0.05).
结论: 埃索美拉唑联合铝碳酸镁和莫沙比利治疗rGERD有很高的临床疗效.
关键词: 胃食管反流病; 埃索美拉唑; 铝碳酸镁; 莫沙比利
王战波, 陈玲玲, 游旭东 ......
王战波, 陈玲玲, 游旭东, 河南平顶山煤业集团总医院消化内科, 河南省平顶山市 467000
通讯作者: 王战波, 467000, 河南省平顶山市, 河南平顶山煤业集团总医院消化内科. guogh2000@hotmail.com
电话: 0375-2729334
收稿日期: 2006-12-10 接受日期: 2006-12-27
Efficacy of esomeprazole combined with hydrotalcite and mosapride in treatment of refractory gastroesophageal reflux disease
Zhan-Bo Wang, Ling-Ling Chen, Xu-Dong You
Zhan-Bo Wang, Ling-Ling Chen, Xu-Dong You,Department of Gastroenterology, General Hospital of Pingdingshan Coal Group, Pingdingshan 467000, He’nan Province, China
Correspondence to:Zhan-Bo Wang, Department of Gastroenterology, General Hospital of Pingdingshan Coal Group, Pingdingshan 467000, Henan Province, China. guogh2000@hotmail.com
Received:2006-12-10 Accepted:2006-12-27
Abstract
AIM:To evaluate the effect of esomeprazole combined with hydrotalcite and mosapride on refractory gastroesophageal reflux disease (rGERD).
METHODS: A total of 101 rGERD patients were randomly divided into groups A (n = 36), B B (n = 34) and C (n = 31), treated with esomeprazole plus hydrotalcite plus mosapride, esomeprazole plus mosapride, and hydrotacite plus mosapride, respectively. The clinical outcomes were observed and analyzed after 4 and 8 weeks of treatment. Endoscopy was performed to evaluate the effective rate in the three groups.
RESULTS: After 4 weeks of treatment, the total improvement rate was significantly higher in group A (88.9%) than that in group B (79.4%) and C (61.3%) (χ2 = 7.3531, P < 0.05). Eight weeks after treatment, the total improvement rates were 97.2%, 88.2% and 71.0% in group A, B and C, ,and the effective rates detected by endoscopy were 94.4%, 85.3% and 67.7%, respectively. The total improvement rate (χ2 = 9.6039, P < 0.01) and effective rate (χ2 = 8.6496, P < 0.05) were markedly higher in group A than those in B and C group.
CONCLUSION: Esomeprazole combined with hydrotalcite and mosapride may be highly effective in the treatment of rGERD.
Key Words: Gastroesophageal reflux disease; Esomeprazole; Hydrotalcite; Mosapride
Wang ZB, Chen LL, You XD. Efficacy of esomeprazole combined with hydrotalcite and mosapride in treatment of refractory gastroesophageal reflux disease. Shijie Huaren Xiaohua Zazhi 2007;15(8):901-904
摘要
目的: 探讨联合应用埃索美拉唑、铝碳酸镁和莫沙比利治疗难治性胃食管反流病 (r-GERD)的临床疗效.
方法: 101例rGERD患者随机为A (n = 36), B (n = 34)和C组(n = 31), 分别采用埃索美拉唑+铝碳酸镁+莫沙比利、埃索美拉唑+莫沙比利及铝碳酸镁+莫沙比利治疗. 4及8 wk后评价临床症状, 8 wk后评价内镜下有效率.
结果: 治疗4 wk后, A, B和C组临床症状总改善率分别为88.9%, 79.4%和61.3%, A组与B, C两组相比差异显著(χ2 = 7.3531, P<0.05). 治疗8 wk后, A, B和C组临床症状总改善率分别为97.2%, 88.2%和71.0%, 内镜下有效率分别为94.4%, 85.3%和67.7%, A组临床症状总改善率和内镜下有效率与B, C组相比存在显著性差异(χ2 = 9.6079, P<0.01; χ2 = 8.6496, P<0.05).
结论: 埃索美拉唑联合铝碳酸镁和莫沙比利治疗rGERD有很高的临床疗效.
关键词: 胃食管反流病; 埃索美拉唑; 铝碳酸镁; 莫沙比利
王战波, 陈玲玲, 游旭东 ......
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