Association between gene polymorphism of XRCC 2 and susceptibility of nonª²small cell lung cancers

    WANG Rui1, ZENG Hui1, LI Yan2, WANG Na2, ZHANG Jianª²Hui3, ZHANG Jinª²Wen4, WANG Wei5, LIU Junª²Feng1,

    1Department of Thoracic Surgery, Fourth Affiliated Hospital, Hebei Medical University, 2Laboratory of Molecular Biology, Hebei Cancer Institute, Shijiazhuang 050011, China, 3National Center for AIDS Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China, 4Operation Room, Thoracic Hospital of Hebei Province, Shijiazhuang 050011, China, 5Department of Surgery, Chengan County Hospital of Hebei Province, Handan 056700, China

    ¡¾Abstract¡¿ AIM: To observe the association between the risk of nonª²small cell lung cancers and polymorphism and gene frequency of XRCC 2 C41657T and G4234C in north Chinese Han population. METHODS: The single nucleotide polymorphisms (SNPs) of the C41657T and G4234C in the XRCC 2 gene were genotyped by PCRª²RFLP analysis in 226 nonª²small cell lung cancer patients and 300 healthy controls. RESULTS: There was XRCC 2 gene C41657T and G4234C polymorphism in north Chinese Han population. The genotype and allelotype distributions of the XRCC 2 C41657T and G4234C SNPs in the nonª²small cell lung cancer patients were not significantly different from those of the controls (all P>0.05). When the two XRCC 2 SNPs were combined, the haplotype distribution in the nonª²small cell lung cancer patients was also not significantly different from that of the controls (P>0.05). But stratification analysis according to histological types and smoking status showed that, compared with C/C genotype, the combination of C/T and T/T genotypes of XRCC 2 C41657T increased the risk of developing nonª²small cell lung cancer (OR: 1.85, 95% CI: 1.02-3.36 ) and that of adenosquamous carcinoma (OR: 2.45, 95% CI=1.05-5.72) in nonª²smokers. No association was observed between XRCC2 G4234C and the type of nonª²small cell lung cancers, and also there was no evidence for the interaction between XRCC 2 G4234C and smoking status(P>0.05). CONCLUSION: XRCC 2 gene C41657T allele may be a susceptibility factor for the development of nonª²small cell lung cancer and adenosquamous carcinoma in the nonª²somkers of north Chinese Han population. ......