Expressions of CEA and CA153 in the serum of breast cancer patients and their clinical significances

    ZHANG Luª²Min, ZHAO Wei, LIU Guoª²Jin

    Department of Thoracic Surgery, First Clinical Hospital, Jilin University, Changchun 130021, China

    ¡¾Abstract¡¿ AIM: To study the correlations between the expressions of carcinoª²embryonic antigen (CEA)and CA153 in the serum of breast cancer patients and the genesis, growth and metastasis of breast tumor. METHODS: We collected the serum from 60 patients, including 40 of breast cancer and 20 of benign breast diseases, and then detected the expressions of CEA and CA153 with radioimmunoassay. RESULTS: In 40 breast cancer patients, and the positive rates of CEA and CA153 were 32.5% and 47.5% respectively, the contents of CEA and CA153 were (21.55¡À6.96) ¦Ìg/L and (37.63¡À23.22) U/mL respectively;they were obviously higher than those in the control group (20 benign breast disease patients) (P<0.01). There were positive correlations between the contents of CEA and CA153 and the histological grade, tumor size and the axillary lymph node metastasis (P<0.01). CONCLUSION: CEA and CA153 have close relations with the genesis, growth, biological behavior and metastasis of breast tumor. The comprehensive detection of these indexes is useful for the early diagnosis and beneficial for a good prognosis of breast cancer patients. ......