齐墩果酸；固体脂质纳米粒；质量评价_

齐墩果酸固体脂质纳米粒的制备与质量评价

http://www.100md.com 《第四军医大学学报》 2000年第5期

齐墩果酸；固体脂质纳米粒；质量评价,,齐墩果酸；固体脂质纳米粒；质量评价,【关键词】齐墩果酸；固体脂质纳米粒；质量评价,0引言,1材料和方法,2结果,3讨论,【参考文献】

     Preparation and quality evaluation of oleanolic acidloaded solid lipid nanoparticles

    WANG JingWen，TANG HaiFeng， SHEN Min， WANG Li，FANG KunQuan

    Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xian 710033, China

    【Abstract】 AIM: To prepare the oleanolic acidloaded solid lipid nanoparticles (OASLN), determine the content of oleanolic acid in OASLN, and evaluate its quality. METHODS: OASLN were prepared by filmultrasound dispersion technique. The encapsulation efficiency and appearance of solid lipid nanoparticles were studied. RESULTS： The appearance of prepared solid lipid nanoparticles was regular with the diameter being (62.0±10.3) nm, the encapsulation efficiency was 98.29% and the loading rate was 8.17%. CONCLUSION： The selected preparation technique of OASLN is rational and practicable. It provides experimental evidence for developing a new oleanolic acid injection.

    【Keywords】 oleanolic acid； solid lipid nanoparticles； quality evaluation

    【摘要】目的：对齐墩果酸固体脂质纳米粒的制备工艺和含量测定方法进行研究 ......

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