【摘要】 目的 评估中国四个大规模抗高血压临床试验的疗效。 方法 采用固定效应模型进行数据分析。 结果 分析显示平均治疗时间为3.7a，血压平均降低9/4mmHg。脑卒中危险降低36%(95%CI为25%～46%，P<0.001)，心血管死亡和总死亡减少22%和20%(P<0.05)，总的心血管事件减少33%(P<0.001)。冠心病事件减少无显著性差异(P>0.05)。 结论 抗高血压治疗的效果很大程度上源于脑卒中事件的减少。

    【关键字】 随机对照试验;Meta分析;高血压

    Meta-analysis for four large-scale antihypertensive clinical trials

    LI Wei，HE Xin-ye，ZHANG Yu-qing.

    Cardiovascular Instituteand Fu Wai Hospital，CAPM and PUMC National Center for Car-diovascular Diseases，Beijing 100037，China

    【Abstract】 Objective To assess the effect of the four large scale antihypertensive clinical trials with an overall study population of10，457patients which were held in China.Methods The fixed effect model was used for data analysis.Results A pooled analysis at the individual level showed that the average time of treatment was3.7years，after which the average reduction of blood pressure of9/4mmHg was found.Overview showed that stroke was reduced by36%(95%CI25%～46%，P<0.001)，cardio-vascular death and total deaths were reduced by22%and20%respectively(P<0.05) ......