[摘 要] 目的 探讨超声造影剂(SonoVue(r))与实时灰阶造影匹配成像技术观察肝脏局灶性病变的灌注过程、回声变化规律以及对肝恶性肿瘤诊断的应用价值。方法 回顾分析采用静脉快速团注造影剂SonoVue(r)法对39例肝脏局灶性病变造影剂灌注过程。结果 39例中36例超声造影表现符合欧洲医学和生物学超声协会联盟(EFSUMB)对肝脏局灶性病变良、恶性超声造影诊断标准，2例假阳性，1例假阴性。超声造影判别恶性肝脏局灶性病变(Focal liver lesion, FLL)的敏感性为95.83%，特异性为86.67%，阳性预测值92.00%，阴性预测值92.86%，准确性92.30%。结论 实质灰阶超声造影有助于肝局灶性病变的良恶性判断。

    [关键词] 超声造影；肝脏局灶性病变

    The clinical use of contrast-enhanced gray-scale ultrasonography in the diagnosis of focal liver lesions XU Haishan, FAN Xiaoming, TANG Fugang, et al. Department of Ultrasound, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou 310016, China

    [Abstract] Objective To evaluate the diagnostic value of new contrast agent and real time gray-scale contrast ultrasonography in focal liver lesions. Methods Thirty nine cases with focal liver lesions were enrolled in the study. Contrast agent SonoVue(r), Technos DU8 and Logiq9 and their contrast technology were used. The contrast agent was delivered through bolus injection. Results The diagnostic sensitivity, specificity, positive and negative rate and accuracy were 95.83% (23/24), 86.67% (13/15), 92.00% (23/25), 92.86% (13/14) and 92.30% (36/39), respectively. Conclusion Contrast-enhanced gray-scale ultrasonography could play an important role in differential diagnosis of focal liver lesions. ......