胃肿瘤；_幽门螺杆菌感染_；蛋白质Survivin；

幽门螺杆菌感染与胃癌Survivin蛋白表达的关系

http://www.100md.com 《齐鲁医学杂志》 2007年第2期

胃肿瘤；,幽门螺杆菌感染,；蛋白质Survivin；,免疫组织化学,,],胃肿瘤；,幽门螺杆菌感染,；蛋白质Survivin；,免疫组织化学,1材料与方法,2结果,3讨论,[参考文献]

     [摘要] 目的探讨幽门螺杆菌(Hp)感染与胃癌组织中Survivin蛋白表达的关系。方法对60例胃癌及其癌旁组织标本应用尿素酶试验法、WarthinStarry染色法检测Hp，用免疫组化SP法检测Survivin蛋白的表达水平。结果 Hp阳性病人胃癌组织中Survivin蛋白表达率明显高于Hp阴性的胃癌组织(Hc=6.62，P<0.05)，癌旁组织中无Survivin蛋白表达。结论 Hp感染能上调胃癌组织中Survivin蛋白的表达，从而引起细胞凋亡抑制，可能在胃癌的发生中起一定作用。另外，Hp感染能增强肿瘤的侵袭能力，Survivin蛋白可作为胃癌预后不良的重要指标。

    [关键词] 胃肿瘤；幽门螺杆菌感染；蛋白质Survivin；免疫组织化学

    RELATIONSHIP BETWEEN SURVIVIN EXPRESSION AND HELICOBACTER PYLORI INFECTION IN GASTRIC CARCINOMAGUO YAN, ZHAO QINGXI, LIU CHUNXIA (Department of Medicine，Shengli Hospital，Shengli Fuel Administration Bureau，Dongying 257055,China)

    [ABSTRACT]ObjectiveTo study the relationship between Survivin protein expression and Helicobacter pylori infection in gastric carcinoma.MethodsThe Helicobacter pylori infection in gastric carcinoma and neighboring tissues were detected by urease test and WarthinStarry staining.The expression of Survivin was investigated immunohistochemically in 60 patients.Results No Survivin was found in the neighboring tissues in all the patients studied. The expression of Survivin in the Helicobacter pylori positive cases was higher than in the negative cases (Hc=6.62 ......

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