妊娠中期注射HBV免疫球蛋白对其宫内阻断作用
肝炎病毒,乙型；,免疫球蛋白类;妊娠中期;阻断疗法,,],肝炎病毒，,乙型；,免疫球蛋白类;妊娠中期;阻断疗法,1资料和方法,2结果,3讨论,参考文献]
[摘要] 目的 探讨妊娠中期开始注射乙型肝炎免疫球蛋白(HBIG)对HBsAg和HBeAg双阳性孕妇乙型肝炎病毒(HBV)的宫内阻断作用。方法 将病人随机分为2组，治疗组32例,孕16周起肌注HBIG,每4周1次至分娩；对照组31例未予用药。结果 治疗组孕妇HBV DNA水平比对照组显著下降(t=24.202,P<0.05)，其新生儿宫内感染率明显低于对照组(χ2=5.671，P<0.05)。两组孕妇及其新生儿未发现有不良反应。结论 HBsAg和HBeAg双阳性孕妇孕中期多次注射HBIG可有效减少HBV宫内感染发生率。[关键词] 肝炎病毒， 乙型； 免疫球蛋白类;妊娠中期;阻断疗法
A CLINICAL STUDY OF INTERRUPTIVE EFFECTS OF HBV SPECIFIC IMMUNOGLOBULINS ON THE HBsAg+ AND HBeAg+ WOMEN IN MIDTRIMESTER PREGNANCY WANG YUANLI, L SHAOFANG(Department of Gynecology and Obstetrics， Qingdao University Medical College Affiliated Yantai Yuhuangding Hospital， Yantai 265000, China)
[ABSTRACT]ObjectiveTo study the interruptive effect of HBV specific immunoglobulin (HBIG) on HBsAg+ and HBeAg+ in midtrimester women. MethodsHBsAg+ and HBeAg+ midtrimester women were randomly divided into treated group and control group, those in treated group (n=32) received 200 U of HBIG intramuscularly every four weeks before delivery from the 16th week of gestation. For the controls, no medications were used.ResultsThe level of HBV DNA in treated group decreased obviously (P<0.05) and the rate of intrauterine HBV infection was significantly lower than that of the control group (P<0.05). No side effects were found in the women and their neonates. ConclusionMultiple injections of HBV specific immunoglobulin given to HBsAg+ and HBeAg+ midtrimester women may effectively decrease intrauterine infection of HBV. ......
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