小窝蛋白1；基质金属蛋白酶2；膀胱癌；免疫组织化学；腺癌

小窝蛋白1、基质金属蛋白酶2在膀胱癌的表达及其关系

http://www.100md.com 《现代泌尿外科杂志》 2007年第3期

小窝蛋白1；基质金属蛋白酶2；膀胱癌；免疫组织化学；腺癌,,小窝蛋白1；基质金属蛋白酶2；膀胱癌；免疫组织化学；腺癌,1材料与方法,2结果,3讨论,参考文献：

     Expression of CAV1 and MMP2 in bladder cancer and the relationship between them

    Li Hengping, Chen Yirong, Yan Dongwen, Shi Baoguang, Guo Yingfang

    (Department of Urology, Gansu Cancer Hospital; Department of Urology, the Peoples Hospital of Gansu Province; Department of Pathology, the Peoples Hospital of Gansu Province, Lanzhou 730030, China)

    ABSTRACT: Objective To explore the expression of CAV1 and MMP2 in bladder cancer and the relationship between them. Methods The expressions of CAV1 and MMP2 were detected by the SP immunohistochemical method in 77 cases of bladder cancer and 15 cases of normal bladder tissues. Results The positive rates of CAV1 and MMP2 in bladder transitional cell carcinoma and bladder adenocarcinaoma were significantly higher than those of normal bladder tissues, and the positive rates in the deeper cancer invasion were significantly higher than those in superficial bladder cancer. CAV1 was positively associated with MMP2 in bladder cancer but not in normal bladder tissue. Conclusion CAV1 and MMP2 were associated with stage and grade of bladder cancer, which suggested that CAV1 might improve secretion of MMP2. ......

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