摘要 目的：观察热疗联合胸腔内注入白细胞介素-2(IL-2)、顺铂治疗恶性胸腔积液的近期疗效和毒副反应。方法：采用胸腔闭式引流尽可能引净积液，再给予胸腔内注药：IL-2 200万 U，顺铂每次注入40 mg～60 mg，1 次/W，连续注射3 W。A组(n=22)每次注药后4 h内给予射频热疗：1 h/次～1.5 h/次，温度41.5 ℃～43.5 ℃；B组(n=18)为对照组。1个月后观察两组的疗效及不良反应。结果：胸腔内注药加热疗对恶性胸腔积液的有效率为90.9% (20/22 )，优于单纯胸腔内注药组61.1%(11/18 )；两组之间有显著性差异(P<0.05)。结论：胸腔内注药联合热疗治疗恶性胸腔积液效果好，能明显改善患者生活质量。

    关键词 恶性胸腔积液；胸腔闭式引流；白细胞介素-2；顺铂；热疗

    Intrapleural Perfusion Biochemotherapy and Hyperthermia for Malignant Pleural Effusion

    Tian Li,Nie Qing,Yang Ping,et al.

    Oncology Department,Navy General Hospital

    Abstract Objective:To evaluate the response and adverse reactions of intrapleural perfusion biochemotherapy and hyperthermia in the treatment of malignant pleural effusion. Methods: 40 patients with malignant pleural effusion were applied with the closed thoracic drainage and were received intrapleural perfusion of IL-2 and DDP. IL-2 at a dose of 2×106 U every time was injected intrapleurally and that of DDP was 40 mg～60 mg every time.They were divided into two groups. The patients in grope A(n=22) were treated by hyperthermia within four hours after intrapleural perfusion drugs every time, and those in group B (n=18)without hyperthermia. The above dosage was given one time/week for three weeks. The therapeutic effect and adverse reactions were observed after one month. Results: Overall objective response rate(complete +partial remission) of 90.9%(20 /22 ) in the group A was significantly higher than that of 61.1%(11/18 ) in the group B. There was significant difference between two groups(P<0.05). Conclusion: Combination of intrapleural perfusion biochemotherapy and hyperthermia has better effect on malignant pleural effusion and improve the quality of life. ......