缬沙坦分散片的制备及含量测定
缬沙坦分散片；,正交设计；,高效液相色谱法,,缬沙坦分散片；,正交设计；,高效液相色谱法,1材料与方法,2结果,3讨论,参考文献：
摘要：目的研制缬沙坦分散片,并进行含量测定。方法采用正交设计方法优选出制备的最佳条件。利用高效液相色谱法测定不同批号的缬沙坦分散片的含量。结果该品在1 min内可完全崩解且含量测定稳定。结论 用优选处方制备的缬沙坦分散片崩解快,分散均匀且含量测定结果符合限度要求。关键词：缬沙坦分散片； 正交设计； 高效液相色谱法
Preparation and Content Determination of Valsartan Dispersible Tablets
HAN Jun, MA Baoyu, LI Juan
(Department of Pharmacy, Xiangfan No.1 People's Hospital, Xiangfan,441000, China；Department of Pharmacy, Hankou Railway Hospital, Wuhan, 430012，China)
Abstract：ObjectiveTo study the preparation of valsartan dispersible tablets and to determine valsartan content in the formulation.MethodsThe conditions for preparation were optimized by orthogonal design and the determination of valsartan was studied with a HPLC method. ResultsThe tablets could completely disintegrate within 1 min. ConclusionThe dispersible tablets prepared in optimum condition were rapid in disintegration and homogenous in dispersal with a stable content.
Key words：Valsartan dispersible tablet； Orthogonal design； HPLC
缬沙坦(Valsartan ......
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