银杏叶提取物；_肠系膜；_微循环；_槲皮素_

银杏叶提取物对家兔血液循环的影响研究

http://www.100md.com 《时珍国医国药》 2007年第1期

银杏叶提取物；,肠系膜；,微循环；,槲皮素,,银杏叶提取物；,肠系膜；,微循环；,槲皮素,1材料,2方法,3结果,4讨论,参考文献：

     摘要：目的观察银杏叶提取物(Ginkgo biloba extracts EGB)对家兔动脉血压、心率、心电及其肠系膜微循环的影响。方法采用微循环研究技术，随机分为正常对照组、微循环障碍组(NE)、微循环障碍改善组(生理盐水组、EGB低浓度组和EGB高浓度组)，观察各组给药前，给药后15、30min对毛细血管、微静脉、微动脉的管径、血流速度和血流量变化及动脉血压、心率、心电图的变化。结果EGB各组给药后均表现出家兔肠系膜毛细血管、微动脉和微静脉血管扩张，血液流速加快，血流量增加(P<0.05或P<0.01)，EGB对家兔动脉血压、心率、心电没有显著性影响(P>0.05)。结论EGB能使肠系膜毛细血管、微动脉和微静脉血管扩张、血液流速加快、血流量增加而对家兔动脉血压、心率、心电无显著性影响。

    关键词：银杏叶提取物；肠系膜；微循环；槲皮素

    Effects of Ginkgo biloba Extracts on Blood Circulation in Rabbits

    ZHANG Caizhu，YANG Runsheng，PAN Shengwu，SUN Yanyan, YANG Shengchang*

    ( Department of Biology of Guangxi Normal University, Guilin 541004, China )

    Abstract：ObjectiveTo observe the effects of Ginkgo biloba extracts (EGB) on blood pressure, heart rate, electrocardia and mesenteric microcirculation in rabbits. MethodsThe changes of indexes on blood presure, heart rate, electrocardia and microcirculation parameters in rabbits were observed by the technology of microcirculation research. ResultsCompared with the NE group, Ginkgo biloba extracts could dilate the capillary, arteriole and venule, and increase blood flow velocity and blood perfusion in rabbits (P<0.05 or P<0.01). Ginkgo biloba extracts had no significant effects on blood pressure, heart rate and electrocardia in rabbits (P>0.05). ConclusionWe can see that Ginkgo biloba extracts can dilate the capillary, arteriole and venule, and increase blood flow velocity and blood perfusion. But it has no obvious effects on blood pressure, heart rate and electrocardia in rabbits. ......

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