苦碟子注射液；_异丙肾上腺素；_垂体后叶素；

苦碟子注射液对急性心肌缺血的保护作用

http://www.100md.com 《时珍国医国药》 2007年第1期

苦碟子注射液；,异丙肾上腺素；,垂体后叶素；,心肌缺血,,苦碟子注射液；,异丙肾上腺素；,垂体后叶素；,心肌缺血,1材料,2方法与结果,3讨论,参考文献：

     摘要：目的考察苦碟子注射液对实验动物急性心肌缺血的保护作用。方法采用异丙肾上腺素、垂体后叶素造成大鼠心肌缺血模型及结扎冠脉造成麻醉犬心肌缺血模型考察苦碟子注射液对心肌缺血的保护作用。结果苦碟子注射液以3.5，7.0，14.0 g·kg-1连续7 d腹腔注射给药可显著改善异丙肾上腺素、垂体后叶素造成大鼠心肌缺血；1.0，2.0，4.0 g·kg-1单次静脉注射给药明显降低结扎冠脉麻醉开胸犬的心肌梗塞面积，降低血清中乳酸脱氢酶(Lactic Dehydrogenase,LDH)、肌酸激酶(Creatine Kinase ,CK)活性；对冠脉结扎犬心外膜电图的S-T段偏也有显著改善作用(P<0.05或P<0.01)。结论苦碟子注射液对实验动物急性心肌缺血有显著改善作用。

    关键词：苦碟子注射液；异丙肾上腺素；垂体后叶素；心肌缺血

    The Protective Effect of Kudiezi Injection on the Experimental Acute Myocardial Infarction

    ZHOU Xiaomian, JIN Wenshu, CAO Chunyang,CAO Yinglin

    (School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016 ,China; Wantong Pharmaceutical Co.Ltd.,Tonghua,134001 China； The Red Cross Hospital of Shenyang , Shenyang 110013, China)

    Abstract：ObjectiveTo observe the protective effect of Kudiezi Injection(KDI) on dog and rat acute myocardial ischemia.MethodsRat acute myocardial ischemia model was induced by isoprenaline and hypophysin.Dog model was prepared by ligating the left anterior descending coronary artery. ResultsBy intravenous injection(1.0,2.0,4.0 g·kg1),KDI decreased the activities of serum creatine kinase and lactic dehydrogenase, diminished the myocardial ischemia size and ΣST. By peritoneal injection for 7 days(3.5,7.0, 14.0g·kg1),KDI strikingly improved acute myocardial ischemia by isoprenaline and hypophysin in rats (P<0.01). ConclusionKDI is beneficial to experimental acute myocardial ischemia. ......

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