摘要：目的探讨丹参对持续癫痫幼鼠脑神经元损伤可能具有的保护作用及其机制。方法美解眠诱发健康幼龄大鼠癫痫持续状态发作。随机分组后分批处死。电镜观察海马神经元超微结构的改变，ELISA法测定血清 NSE(神经元特异性烯醇化酶)浓度变化。结果丹参治疗组幼鼠电镜下可见海马神经元较轻的超微结构病变和血清NSE浓度在发作后相同时点均低于持续癫痫组。结论丹参对持续癫痫幼鼠脑神经元损伤具有一定的保护作用；血清神经元特异性烯醇化酶与持续癫痫幼鼠神经元损伤变化趋势基本一致，能作为判断脑神经元损伤及其恢复的有效指标。

    关键词：丹参； 惊厥性脑损伤； 神经元特异性烯醇化酶

    Protective Effect of Salvia miltiorrhiza Bge Against Seizure-induced Brain Injury in Young Rats

    LI Wei, MA Hua

    (Department of Internal Medicine, Guangdong Provincial Hospital of Chinese People's Armed Police Forces, Guangzhou 510507, China)

    Abstract：ObjectiveTo evaluate the protective effect and mechanism of Salvia miltiorrhiza Bge(SMB) against seizure-induced cerebral neuron injury of premature rats.MethodsMegimide (20mg/kg) was injected into healthy infant rats(21d) to evoke status epilepticus(SE).The ultrastructure changes of the hippocampus neurons were observed under the electronic microscope.At the same time points,the level of neuron speertic enolale NSE in rat sera was tested with ELISA.ResultsThe hippocampus neurons of SE group rats,the mitochondria volume decreased,the matrix condensed,the ridge obscured or disappeared.Compared with the SE group, there was a significant improvement in nutron injury in SMB group.The SE group rats in the 72 h after seizures had a high level of NSE in sera.But the SMB group was lower.ConclusionSalvia miltiorrhiza Bge has a positive effect on the seizure-induced brain neuron injury of premature rats.The serum NSE may be an effective marker used to tell the existence of neuron injury and point out the recovery. ......