地锦草；_总黄酮；_急性肝损伤；_四氯化碳_

地锦草总黄酮预防四氯化碳所致急性肝损伤的实验研究

http://www.100md.com 《时珍国医国药》 2007年第1期

地锦草；,总黄酮；,急性肝损伤；,四氯化碳,,地锦草；,总黄酮；,急性肝损伤；,四氯化碳,1材料与方法,2结果,3讨论,参考文献：

     摘要：目的研究地锦草总黄酮(total flavonoids of Euphorbiae humifusae，TFEH) 对四氯化碳造成的小鼠急性肝损伤的保护作用。方法四氯化碳造成小鼠急性肝损伤模型,测定血清谷丙转氨酶(serum glutamic pyruvic transaminase,SGPT)、肝组织谷丙转氨酶(liver glutamic pyruvic transaminase,GPT)、超氧化物歧化酶(superoxidase dismutase,SOD)活性及丙二醛(malonaldehyde,MDA)、还原性谷胱甘肽(GSH)含量,采用光镜观察肝脏组织学变化。结果与四氯化碳模型组比较,经TFEH预防性治疗后,GPT、LGPT活性和MDA含量均明显降低(P<0.05或P<0.01),而GSH含量和SOD活力明显增高(P<0.05)。通过病理学切片观察,TFEH明显改善肝组织的病理变化。结论TFEH对四氯化碳造成的小鼠急性肝损伤具有保护作用。

    关键词：地锦草；总黄酮；急性肝损伤；四氯化碳

    Protective Effect of Total Flavonoids of Herba Euphorbiae humifusae against Hepatic Injury Induced by CCl4 in Mice

    CAO Ruizhen, WEI Yongchun, QIANG Xin, QIAO Wei

    (Inner Mongolian University for Nationalities，Tongliao 028041, China)

    Abstract：ObjectiveThe protective effect of total flavonoids Euphorbiae humifusae against CCl4-induced hepatic injury in mice was observed. MethodsAcute liver injury model in mice was made by using CCl4. The levels of SGPT, LGPT in serum and MDA, SOD,GSH in liver and hepatic pathological tissue were observed. ResultsCompared with model control group, the levels of serum SGPT, LGPT, liver MDA of the mice treated with TFEH significantly decreased(P<0.05 or P<0.01),while the activity of SOD and the level of GSH increased greatly(P<0.05). By observation of pathological slices, TFEH could improve hepatic pathological changes distinctly. ConclusionTFEH can prevent CCl4-induced hepatic injury. ......

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